Antimicrobial peptides: Difference between revisions
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== AMPs structures == | == AMPs structures == | ||
As we mentioned earlier, Although AMPs have the same effect on the cell mambrane, they do not seem to have the same structure. we can find a big variety of structures among familiar AMPs. (1) Some have helical structures, for some of the peptide sequence, such as Magainin, (2LSA), or a helical structure throughout the whole peptide, such as Magainin2 (2MAG). this peptide was found on a frogs skin. you can see the page about Magainin2 | As we mentioned earlier, Although AMPs have the same effect on the cell mambrane, they do not seem to have the same structure. we can find a big variety of structures among familiar AMPs. (1) Some have helical structures, for some of the peptide sequence, such as Magainin, (2LSA), or a helical structure throughout the whole peptide, such as Magainin2 (2MAG). this peptide was found on a frogs skin. you can see the page about Magainin2 here : [[2mag]]. | ||
(2) Beta-sheet structures: | (2) Beta-sheet structures: | ||
<scene name='67/676980/1hvz_-_cyclic_peptide/1'> | <scene name='67/676980/1hvz_-_cyclic_peptide/1'>RTD1</scene>, A cyclic antimicrobial defencin from ''Rhesus Macaque leukocytes'',has a beta sheet structure, rich with disulfide bonds that strengthen the beta-sheet structure. this peptide is 55% beta sheet (4 strands; 10 residues). | ||
<scene name='67/676980/1pg1_cationic_residues_a/1'>Protegrin 1</scene> from porcine leukocytes, NMR, has a hairpin shape | <scene name='67/676980/1pg1_cationic_residues_a/1'>Protegrin 1</scene> from porcine leukocytes, NMR, has a hairpin shape | ||
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Protegrins are a family of arginine - and cysteine rich cationic peptides | Protegrins are a family of arginine - and cysteine rich cationic peptides | ||
(c) and some have combined structures, like | (c) and some have combined structures, like <scene name='67/676980/1ijv_lysin/1'>Human beta defencin1</scene> | ||
