2wqb: Difference between revisions
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==Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor== | ==Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor== | ||
<StructureSection load='2wqb' size='340' side='right' caption='[[2wqb]], [[Resolution|resolution]] 2.95Å' scene=''> | <StructureSection load='2wqb' size='340' side='right' caption='[[2wqb]], [[Resolution|resolution]] 2.95Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2wqb]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WQB OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2WQB FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QQ1:2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE'>QQ1</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QQ1:2-[3-(CYCLOHEXYLMETHYL)-5-PHENYL-IMIDAZOL-4-YL]-[1,3]THIAZOLO[4,5-E]PYRIMIDIN-7-AMINE'>QQ1</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gy5|2gy5]], [[1fvr|1fvr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2gy5|2gy5]], [[1fvr|1fvr]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Receptor_protein-tyrosine_kinase Receptor protein-tyrosine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.10.1 2.7.10.1] </span></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqb OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2wqb RCSB], [http://www.ebi.ac.uk/pdbsum/2wqb PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2wqb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wqb OCA], [http://pdbe.org/2wqb PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2wqb RCSB], [http://www.ebi.ac.uk/pdbsum/2wqb PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2wqb ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2wqb ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2wqb" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Human]] | ||
[[Category: Receptor protein-tyrosine kinase]] | [[Category: Receptor protein-tyrosine kinase]] | ||
[[Category: Brassington, C]] | [[Category: Brassington, C]] | ||
Revision as of 10:08, 11 August 2016
Structure of the Tie2 kinase domain in complex with a thiazolopyrimidine inhibitor
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Human
- Receptor protein-tyrosine kinase
- Brassington, C
- Breed, J
- Buttar, D
- Fitzek, M
- Forder, C
- Hassall, L
- Hayter, B R
- Jones, C D
- Luke, R W.A
- McCall, E
- McCoull, W
- McMiken, H
- Norman, R
- Paterson, D
- Rowsell, S
- Tucker, J A
- Atp-binding
- Disease mutation
- Glycoprotein
- Kinase
- Nucleotide-binding
- Oncology
- Phosphoprotein
- Phosphotransferase
- Receptor
- Thiazolopyrimidine
- Transferase
- Tyrosine-protein kinase
