2oto: Difference between revisions

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'''N-terminal fragment of Streptococcus pyogenes M1 protein'''

==Overview==

Antigenically variable M proteins are major virulence factors and immunogens of the human pathogen group A Streptococcus (GAS). Here, we report the approximately 3 angstrom resolution structure of a GAS M1 fragment containing the regions responsible for eliciting type-specific, protective immunity and for binding fibrinogen, which promotes M1 proinflammatory and antiphagocytic functions. The structure revealed substantial irregularities and instabilities throughout the coiled coil of the M1 fragment. Similar structural irregularities occur in myosin and tropomyosin, explaining the patterns of cross-reactivity seen in autoimmune sequelae of GAS infection. Sequence idealization of a large segment of the M1 coiled coil enhanced stability but diminished fibrinogen binding, proinflammatory effects, and antibody cross-reactivity, whereas it left protective immunogenicity undiminished. Idealized M proteins appear to have promise as vaccine immunogens.

==About this Structure==

2OTO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTO OCA].

==Reference==

Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence., McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P, Science. 2008 Mar 7;319(5868):1405-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18323455 18323455]

[[Category: Single protein]]

[[Category: Streptococcus pyogenes serotype m1]]

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[[Category: virulence factor]]

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@@ Line 11: / Line 11: @@
 '''N-terminal fragment of Streptococcus pyogenes M1 protein'''
+==Overview==
+Antigenically variable M proteins are major virulence factors and immunogens of the human pathogen group A Streptococcus (GAS). Here, we report the approximately 3 angstrom resolution structure of a GAS M1 fragment containing the regions responsible for eliciting type-specific, protective immunity and for binding fibrinogen, which promotes M1 proinflammatory and antiphagocytic functions. The structure revealed substantial irregularities and instabilities throughout the coiled coil of the M1 fragment. Similar structural irregularities occur in myosin and tropomyosin, explaining the patterns of cross-reactivity seen in autoimmune sequelae of GAS infection. Sequence idealization of a large segment of the M1 coiled coil enhanced stability but diminished fibrinogen binding, proinflammatory effects, and antibody cross-reactivity, whereas it left protective immunogenicity undiminished. Idealized M proteins appear to have promise as vaccine immunogens.
 ==About this Structure==
 OTO is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Streptococcus_pyogenes_serotype_m1 Streptococcus pyogenes serotype m1]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2OTO OCA].
+==Reference==
+Coiled-coil irregularities and instabilities in group A Streptococcus M1 are required for virulence., McNamara C, Zinkernagel AS, Macheboeuf P, Cunningham MW, Nizet V, Ghosh P, Science. 2008 Mar 7;319(5868):1405-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/18323455 18323455]
 [[Category: Single protein]]
 [[Category: Streptococcus pyogenes serotype m1]]
@@ Line 24: / Line 30: @@
 [[Category: virulence factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:04:22 2008''
+''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 23 15:34:50 2008''