Tachyplesin: Difference between revisions

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The sequence adapts antiparallel β-sheet (hairpin) conformation in solution stabilized by two cross-strand <scene name='67/671725/Disulfide_bonds/4'> disulfide bonds </scene> between Cys³-Cys¹⁶ and Cys⁷-Cys¹²<ref name=Nakamura>Nakamura, Takanori, et al. "Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (''Tachypleus tridentatus''). Isolation and chemical structure." Journal of Biological Chemistry 263.32 (1988): 16709-16713</ref>, and [http://en.wikipedia.org/wiki/Protein_primary_structure C-terminus amidation].<ref name=Laederach>PMID:12369825</ref><ref name=Kushibiki>PMID:24389234</ref>. In addition there are H-bonds and aromatic rings stacking interactions which helps stabilize the hairpin loop structure of the peptide.

The sequence adapts an antiparallel β-sheet (hairpin) conformation in solution stabilized by two cross-strand <scene name='67/671725/Disulfide_bonds/4'> disulfide bonds </scene> between Cys³-Cys¹⁶ and Cys⁷-Cys¹²<ref name=Nakamura>Nakamura, Takanori, et al. "Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (''Tachypleus tridentatus''). Isolation and chemical structure." Journal of Biological Chemistry 263.32 (1988): 16709-16713</ref>, and [http://en.wikipedia.org/wiki/Protein_primary_structure C-terminus amidation].<ref name=Laederach>PMID:12369825</ref><ref name=Kushibiki>PMID:24389234</ref>. In addition there are H-bonds and aromatic rings stacking interactions which helps stabilize the hairpin loop structure of the peptide.

The β-hairpin structure is well characterized by a <scene name='67/671725/Beta_turn_tp-1/2'>β-turn</scene> for the centrally located residues <scene name='67/671725/Tyrargglyile/3'>Tyr-Arg-Gly-Ile</scene>.<ref name=Saravanan>PMID:22464970</ref>

Tachyplesin: Difference between revisions

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Revision as of 17:27, 22 January 2015 view source Janak Raj Joshi (talk \| contribs) 88 edits No edit summary ← Older edit		Revision as of 17:29, 22 January 2015 view source Janak Raj Joshi (talk \| contribs) 88 edits No edit summary Newer edit →
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	The sequence adapts antiparallel β-sheet (hairpin) conformation in solution stabilized by two cross-strand <scene name='67/671725/Disulfide_bonds/4'> disulfide bonds </scene> between Cys³-Cys¹⁶ and Cys⁷-Cys¹²<ref name=Nakamura>Nakamura, Takanori, et al. "Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (''Tachypleus tridentatus''). Isolation and chemical structure." Journal of Biological Chemistry 263.32 (1988): 16709-16713</ref>, and [http://en.wikipedia.org/wiki/Protein_primary_structure C-terminus amidation].<ref name=Laederach>PMID:12369825</ref><ref name=Kushibiki>PMID:24389234</ref>. In addition there are H-bonds and aromatic rings stacking interactions which helps stabilize the hairpin loop structure of the peptide.		The sequence adapts an antiparallel β-sheet (hairpin) conformation in solution stabilized by two cross-strand <scene name='67/671725/Disulfide_bonds/4'> disulfide bonds </scene> between Cys³-Cys¹⁶ and Cys⁷-Cys¹²<ref name=Nakamura>Nakamura, Takanori, et al. "Tachyplesin, a class of antimicrobial peptide from the hemocytes of the horseshoe crab (''Tachypleus tridentatus''). Isolation and chemical structure." Journal of Biological Chemistry 263.32 (1988): 16709-16713</ref>, and [http://en.wikipedia.org/wiki/Protein_primary_structure C-terminus amidation].<ref name=Laederach>PMID:12369825</ref><ref name=Kushibiki>PMID:24389234</ref>. In addition there are H-bonds and aromatic rings stacking interactions which helps stabilize the hairpin loop structure of the peptide.

	The β-hairpin structure is well characterized by a <scene name='67/671725/Beta_turn_tp-1/2'>β-turn</scene> for the centrally located residues <scene name='67/671725/Tyrargglyile/3'>Tyr-Arg-Gly-Ile</scene>.<ref name=Saravanan>PMID:22464970</ref>		The β-hairpin structure is well characterized by a <scene name='67/671725/Beta_turn_tp-1/2'>β-turn</scene> for the centrally located residues <scene name='67/671725/Tyrargglyile/3'>Tyr-Arg-Gly-Ile</scene>.<ref name=Saravanan>PMID:22464970</ref>