Tachyplesin: Difference between revisions
From Proteopedia
Jump to navigationJump to search
No edit summary |
No edit summary |
||
| Line 18: | Line 18: | ||
TP-I undergoes a conformational change in the <scene name='67/671725/Tp_i_in_the_presence_of_lps/1'>presence of LPS </scene>. The backbone of the polypeptide becomes <scene name='67/671725/Conformation_change/8'>more rigid and twisted in the presence of LPS, than in the presence of water</scene>, making it more stable. | TP-I undergoes a conformational change in the <scene name='67/671725/Tp_i_in_the_presence_of_lps/1'>presence of LPS </scene>. The backbone of the polypeptide becomes <scene name='67/671725/Conformation_change/8'>more rigid and twisted in the presence of LPS, than in the presence of water</scene>, making it more stable. | ||
Along with the requirement for β-hairpin conformation, there is a second requirement for activity and it is the ability to rearrange to a more amphiphilic conformation upon membrane association. | |||
In the wild type | |||
