2xm7: Difference between revisions
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==STRUCTURAL AND MECHANISTIC ANALYSIS OF THE MAGNESIUM-INDEPENDENT AROMATIC PRENYLTRANSFERASE CLOQ FROM THE CLOROBIOCIN BIOSYNTHETIC PATHWAY== | ==STRUCTURAL AND MECHANISTIC ANALYSIS OF THE MAGNESIUM-INDEPENDENT AROMATIC PRENYLTRANSFERASE CLOQ FROM THE CLOROBIOCIN BIOSYNTHETIC PATHWAY== | ||
<StructureSection load='2xm7' size='340' side='right' caption='[[2xm7]], [[Resolution|resolution]] 2.22Å' scene=''> | <StructureSection load='2xm7' size='340' side='right' caption='[[2xm7]], [[Resolution|resolution]] 2.22Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2xm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2xm7]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/'streptomyces_roseochromogenes_subsp._oscitans' 'streptomyces roseochromogenes subsp. oscitans']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2XM7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2XM7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34H:(2R)-2-HYDROXY-3-(4-HYDROXYPHENYL)PROPANOIC+ACID'>34H</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=34H:(2R)-2-HYDROXY-3-(4-HYDROXYPHENYL)PROPANOIC+ACID'>34H</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FMT:FORMIC+ACID'>FMT</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xm5|2xm5]], [[2xlq|2xlq]], [[2xly|2xly]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2xm5|2xm5]], [[2xlq|2xlq]], [[2xly|2xly]]</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xm7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2xm7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xm7 PDBsum]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2xm7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2xm7 OCA], [http://pdbe.org/2xm7 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2xm7 RCSB], [http://www.ebi.ac.uk/pdbsum/2xm7 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2xm7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/CLOQ_STRRC CLOQ_STRRC]] Magnesium-independent aromatic prenyltransferase that catalyzes the irreversible transfer of a dimethylallyl group to 4-hydroxyphenylpyruvate to produce the ring A structure in the clorobiocin biosynthesis pathway. Clorobiocin is an aminocoumarin family antibiotic.<ref>PMID:12618544</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 2xm7" style="background-color:#fffaf0;"></div> | |||
== References == | == References == | ||
<references/> | <references/> | ||
