2p59: Difference between revisions

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|PDB= 2p59 |SIZE=350|CAPTION= <scene name='initialview01'>2p59</scene>, resolution 2.900&Aring;
|PDB= 2p59 |SIZE=350|CAPTION= <scene name='initialview01'>2p59</scene>, resolution 2.900&Aring;
|SITE= <scene name='pdbsite=AC1:Gg4+Binding+Site+For+Residue+B+1208'>AC1</scene>
|SITE= <scene name='pdbsite=AC1:Gg4+Binding+Site+For+Residue+B+1208'>AC1</scene>
|LIGAND= <scene name='pdbligand=GG4:'>GG4</scene>
|LIGAND= <scene name='pdbligand=GG4:(2S,3AS,7AS)-1-[(2S)-2-{[(2S)-2-CYCLOHEXYL-2-({[(2R)-4-NITRO-2H-PYRROL-2-YL]CARBONYL}AMINO)ACETYL]AMINO}-3,3-DIMETHYLBUTANOYL]-N-{(1S)-1-[(1R)-2-(CYCLOPROPYLAMINO)-1-HYDROXY-2-OXOETHYL]BUTYL}OCTAHYDRO-1H-INDOLE-2-CARBOXAMIDE'>GG4</scene>
|ACTIVITY=  
|ACTIVITY=  
|GENE= NS3 protease domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=54290 GB virus C])
|GENE= NS3 protease domain ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=11103 Hepatitis C virus])
|DOMAIN=
|RELATEDENTRY=
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2p59 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2p59 OCA], [http://www.ebi.ac.uk/pdbsum/2p59 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2p59 RCSB]</span>
}}
}}


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==About this Structure==
==About this Structure==
2P59 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Gb_virus_c Gb virus c]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P59 OCA].  
2P59 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Hepatitis_c_virus Hepatitis c virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2P59 OCA].  


==Reference==
==Reference==
Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics., Perni RB, Chandorkar G, Cottrell KM, Gates CA, Lin C, Lin K, Luong YP, Maxwell JP, Murcko MA, Pitlik J, Rao G, Schairer WC, Van Drie J, Wei Y, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3406-11. Epub 2007 Apr 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17482818 17482818]
Inhibitors of hepatitis C virus NS3.4A protease. Effect of P4 capping groups on inhibitory potency and pharmacokinetics., Perni RB, Chandorkar G, Cottrell KM, Gates CA, Lin C, Lin K, Luong YP, Maxwell JP, Murcko MA, Pitlik J, Rao G, Schairer WC, Van Drie J, Wei Y, Bioorg Med Chem Lett. 2007 Jun 15;17(12):3406-11. Epub 2007 Apr 3. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/17482818 17482818]
[[Category: Gb virus c]]
[[Category: Hepatitis c virus]]
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Perni, R B.]]
[[Category: Perni, R B.]]
[[Category: Wei, Y.]]
[[Category: Wei, Y.]]
[[Category: GG4]]
[[Category: hcv protease]]
[[Category: hcv protease]]
[[Category: viral protein]]
[[Category: viral protein]]


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