Antimicrobial peptides: Difference between revisions
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In the Transmembrane Pore Models, it is suggested that AMPs form many pores in the mambrane, so that it cannot hold it's content anymore. | In the Transmembrane Pore Models, it is suggested that AMPs form many pores in the mambrane, so that it cannot hold it's content anymore. | ||
tha transmembrane pore mechanism has 2 main models: | tha transmembrane pore mechanism has 2 main models: | ||
1- barrel stave pore model ,that claims peptides interact laterally with one another to form a specific structure enclosing a water-filled channel, much like a protein ion channel. [[Image: | 1- barrel stave pore model ,that claims peptides interact laterally with one another to form a specific structure enclosing a water-filled channel, much like a protein ion channel. [[Image:Barrel_stave_pore_model.jpg]] | ||
2- toroidal pore model, that claims specific peptide–peptide interactions are not present, and instead, single peptides are bound to the membrane’s phospholipids and disturbe it’s structure.. | 2- toroidal pore model, that claims specific peptide–peptide interactions are not present, and instead, single peptides are bound to the membrane’s phospholipids and disturbe it’s structure.. | ||
the Nonepore model claims peptides bind to the membrane until it collapses. It is devided into 2 main mechanisms: | the Nonepore model claims peptides bind to the membrane until it collapses. It is devided into 2 main mechanisms: | ||
