4s1f: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone==

~~The entry~~ 4s1f is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4s1f]] is a 20 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1F OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1F FirstGlance].

~~Authors~~: ~~Stellmacher~~, L., ~~Sandalova~~, T., ~~Leptihn~~, S., ~~Schneider, G~~.~~, Sprenger, G~~.A., ~~Samland, A~~.K.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=P2D:PENTANE-2,4-DIONE'>P2D</scene></td></tr>

~~Description~~: ~~Fructose-~~6-phosphate ~~aldolase A~~ from E.~~coli soaked~~ in ~~acetylacetone~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1f OCA], [http://pdbe.org/4s1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s1f RCSB], [http://www.ebi.ac.uk/pdbsum/4s1f PDBsum]</td></tr>

[~~[Category~~: ~~Unreleased Structures]~~]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI]] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Leptihn, S]]

[[Category: Samland, A.K]]

[[Category: Samland, A K]]

[[Category: Sandalova, T]]

[[Category: Schneider, G]]

[[Category: Sprenger, G.A]]

[[Category: Sprenger, G A]]

[[Category: Stellmacher, L]]

[[Category: Cytosol]]

[[Category: Fructose-6-phosphate aldolase some]]

[[Category: Homodecamer]]

[[Category: Lyase]]

[[Category: Modification of active lys85 by acetylacetone]]

[[Category: Tim barrel]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone==
+<StructureSection load='4s1f' size='340' side='right' caption='[[4s1f]], [[Resolution|resolution]] 2.24&Aring;' scene=''>
-The entry 4s1f is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4s1f]] is a 20 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S1F OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S1F FirstGlance]. <br>
-Authors: Stellmacher, L., Sandalova, T., Leptihn, S., Schneider, G., Sprenger, G.A., Samland, A.K.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=P2D:PENTANE-2,4-DIONE'>P2D</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1l6w|1l6w]], [[4rxf|4rxf]], [[4rxg|4rxg]], [[4rz4|4rz4]]</td></tr>
-Description: Fructose-6-phosphate aldolase A from E.coli soaked in acetylacetone
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s1f FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s1f OCA], [http://pdbe.org/4s1f PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4s1f RCSB], [http://www.ebi.ac.uk/pdbsum/4s1f PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/FSAA_ECOLI FSAA_ECOLI]] Catalyzes the reversible formation of fructose 6-phosphate from dihydroxyacetone (DHA) and D-glyceraldehyde 3-phosphate via an aldolization reaction. Can utilize several aldehydes as acceptor compounds in vitro, and hydroxyacetone (HA) or 1-hydroxy-butan-2-one as alternative donor substrate. Is also able to catalyze the direct stereoselective self-aldol addition of glycolaldehyde to furnish D-(-)-threose, and cross-aldol reactions of glycolaldehyde to other aldehyde acceptors. Is not able to cleave fructose, fructose 1-phosphate, glucose 6-phosphate, sedoheptulose 1,7-bisphosphate, xylulose 5-phosphate, ribulose 5-phosphate, and fructose 1,6-bisphosphate; cannot use dihydroxyacetone phosphate as donor compound nor D-glyceraldehyde as acceptor. Does not display transaldolase activity.<ref>PMID:11120740</ref> [HAMAP-Rule:MF_00496]<ref>PMID:17985886</ref> <ref>PMID:19554584</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Leptihn, S]]
-[[Category: Samland, A.K]]
+[[Category: Samland, A K]]
 [[Category: Sandalova, T]]
 [[Category: Schneider, G]]
-[[Category: Sprenger, G.A]]
+[[Category: Sprenger, G A]]
 [[Category: Stellmacher, L]]
+[[Category: Cytosol]]
+[[Category: Fructose-6-phosphate aldolase some]]
+[[Category: Homodecamer]]
+[[Category: Lyase]]
+[[Category: Modification of active lys85 by acetylacetone]]
+[[Category: Tim barrel]]