Antimicrobial peptides: Difference between revisions

Line 128:

==Suggested Mechanisms==

The ~~way different antimicrobial~~ peptides ~~achieve their goal appears~~ to be ~~different~~, and ~~there are a few suggested mechanisms~~.

For killing the bacteria, AMPs must first attracted to bacterial surfaces. The attraction is electrostatic bonding between anionic or cationic peptides and structures on the bacteria's membrane. Studies on membrane models contained vary compositions of charged phospholipids proved this mechanism of attraction. But, bacteria membranes are more complex than mebrane models. Gram negative - Cationic AMPS suggested to be attracted to the net negative charge on the puter mmebrane (phospholipids to phosphate groupf of lipopolysacharides). Gram positive - AMPSs suggested to be attracted to the trichoic acids ob the surface.

Now, the peptides are attached to the cell. However they have to tranverse the lipopolysacharides or extracellular polysacharides so they can contact and act on the outer membrane. the specific mechanism of this step is unclear so far.

There are a few suggested machanisms of how AMPs work(William C. Wimley, ACS CHEMICAL BIOLOGY, 2010).

The way how different antimicrobial peptides insert and act on the membrane goal appears to be different and depends on the peptide, the membrane and the peptide/lipid ratio.

At low peptide/lipid ratios, peptides are oriented parralel to the lipid bilayer,

As the peptide/lipid ration increases, peptides are oriented prependicular to the membrane and insert inside it, forming transmembranes pores.

There are a few suggested machanisms of how AMPs work (William C. Wimley, ACS CHEMICAL BIOLOGY, 2010).

They can be divided into two:

(A) Transmembrane Pore Models of AMP Membrane Activity and (B) Nonpore Models of AMP Activity

Antimicrobial peptides: Difference between revisions

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@@ Line 128: / Line 128: @@
 ==Suggested Mechanisms==
-The way different antimicrobial peptides achieve their goal appears to be different, and there are a few suggested mechanisms.
+For killing the bacteria, AMPs must first attracted to bacterial surfaces. The attraction is electrostatic bonding between anionic or cationic peptides and structures on the bacteria's membrane. Studies on membrane models contained vary compositions of charged phospholipids proved this mechanism of attraction. But, bacteria membranes are more complex than mebrane models. Gram negative - Cationic AMPS suggested to be attracted to the net negative charge  on the puter mmebrane (phospholipids to phosphate groupf of lipopolysacharides). Gram positive - AMPSs suggested to be attracted to the trichoic acids ob the surface.
+Now, the peptides are attached to the cell. However they have to tranverse the lipopolysacharides or extracellular polysacharides so they can contact and act on the outer membrane. the specific mechanism of this step is unclear so far.
-There are a few suggested machanisms of how AMPs work(William C. Wimley, ACS CHEMICAL BIOLOGY, 2010).
+The way how different antimicrobial peptides insert and act on the membrane goal appears to be different and depends on the peptide, the membrane and the peptide/lipid ratio.
+At low peptide/lipid ratios, peptides are oriented parralel to the lipid bilayer,
+As the peptide/lipid ration increases, peptides are oriented prependicular to the membrane and insert inside it, forming transmembranes pores.
+There are a few suggested machanisms of how AMPs work (William C. Wimley, ACS CHEMICAL BIOLOGY, 2010).
 They can be divided into two:
 (A) Transmembrane Pore Models of AMP Membrane Activity and (B) Nonpore Models of AMP Activity