4s2v: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==E. coli RppH structure, KI soak==

~~The entry~~ 4s2v is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4s2v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S2V OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S2V FirstGlance].

~~Authors~~: ~~Vasilyev~~, N., ~~Serganov~~, A.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4s2w|4s2w]], [[4s2x|4s2x]], [[4s2y|4s2y]]</td></tr>

~~Description~~: E. coli ~~RppH structure~~, ~~KI soak~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s2v RCSB], [http://www.ebi.ac.uk/pdbsum/4s2v PDBsum]</td></tr>

~~[[Category: Unreleased Structures]]~~

</table>

== Function ==

[[http://www.uniprot.org/uniprot/RPPH_ECOLI RPPH_ECOLI]] Master regulator of 5'-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa- and tetra-phosphate. Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.<ref>PMID:10760174</ref> <ref>PMID:18202662</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Serganov, A]]

[[Category: Vasilyev, N]]

[[Category: Hydrolase]]

[[Category: Nudix hydrolase]]

[[Category: Rna pyrophosphohydrolase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==E. coli RppH structure, KI soak==
+<StructureSection load='4s2v' size='340' side='right' caption='[[4s2v]], [[Resolution|resolution]] 1.70&Aring;' scene=''>
-The entry 4s2v is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4s2v]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4S2V OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4S2V FirstGlance]. <br>
-Authors: Vasilyev, N., Serganov, A.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4s2w|4s2w]], [[4s2x|4s2x]], [[4s2y|4s2y]]</td></tr>
-Description: E. coli RppH structure, KI soak
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4s2v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4s2v OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4s2v RCSB], [http://www.ebi.ac.uk/pdbsum/4s2v PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/RPPH_ECOLI RPPH_ECOLI]] Master regulator of 5'-dependent mRNA decay. Accelerates the degradation of transcripts by removing pyrophosphate from the 5'-end of triphosphorylated RNA, leading to a more labile monophosphorylated state that can stimulate subsequent ribonuclease cleavage. Preferentially hydrolyzes diadenosine penta-phosphate with ATP as one of the reaction products. Also able to hydrolyze diadenosine hexa- and tetra-phosphate. Has no activity on diadenosine tri-phosphate, ADP-ribose, NADH and UDP-glucose. In the meningitis causing strain E.coli K1, has been shown to play a role in HBMEC (human brain microvascular endothelial cells) invasion in vitro.<ref>PMID:10760174</ref> <ref>PMID:18202662</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Serganov, A]]
 [[Category: Vasilyev, N]]
+[[Category: Hydrolase]]
+[[Category: Nudix hydrolase]]
+[[Category: Rna pyrophosphohydrolase]]