4xo2: Difference between revisions
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''' | ==crystal structure of GnsA from E.coli== | ||
<StructureSection load='4xo2' size='340' side='right' caption='[[4xo2]], [[Resolution|resolution]] 1.95Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4xo2]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XO2 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XO2 FirstGlance]. <br> | |||
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xo1|4xo1]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xo2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xo2 RCSB], [http://www.ebi.ac.uk/pdbsum/4xo2 PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GNSA_ECOLI GNSA_ECOLI]] Overexpression increases levels of unsaturated fatty acids and suppresses both the temperature-sensitive fabA6 mutation and cold-sensitive secG null mutation.<ref>PMID:11544213</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Escherichia Coli GnsA is a regulator of phosphatidylethanolamine synthesis and functions as a suppressor of both a secG null mutation and fabA6 mutations. GnsA may also be a toxin with the cognate antitoxin YmcE. Here we report the crystal structure of GnsA to 1.8 A. GnsA forms a V shaped hairpin structure that is tightly associated into a homodimer. Our comprehensive structural study suggests that GnsA is structurally similar to an outer membrane protein, suggesting a function of protein binding. | |||
Crystal structure of GnsA from Escherichia coli.,Wei Y, Zhan L, Gao Z, Prive GG, Dong Y Biochem Biophys Res Commun. 2015 Jun 19;462(1):1-7. doi:, 10.1016/j.bbrc.2015.03.133. Epub 2015 Apr 1. PMID:25839658<ref>PMID:25839658</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Gao, Z | __TOC__ | ||
</StructureSection> | |||
[[Category: Dong, Y H]] | |||
[[Category: Gao, Z Q]] | |||
[[Category: Wei, Y]] | [[Category: Wei, Y]] | ||
[[Category: Zhan, L | [[Category: Zhan, L H]] | ||
[[Category: | [[Category: Suppressor]] | ||
Revision as of 15:03, 17 June 2015
crystal structure of GnsA from E.coli
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