5aga: Difference between revisions
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''' | ==Crystal structure of the Helicase domain of human DNA polymerase theta in complex with AMPPNP== | ||
<StructureSection load='5aga' size='340' side='right' caption='[[5aga]], [[Resolution|resolution]] 2.90Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5aga]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AGA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AGA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=K:POTASSIUM+ION'>K</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_DNA_polymerase DNA-directed DNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.7 2.7.7.7] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5aga FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5aga OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5aga RCSB], [http://www.ebi.ac.uk/pdbsum/5aga PDBsum]</span></td></tr> | |||
[[ | </table> | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/DPOLQ_HUMAN DPOLQ_HUMAN]] Has a DNA polymerase activity on nicked double-stranded DNA and on a singly primed DNA template. The enzyme activity is resistant to aphidicolin, and inhibited by dideoxynucleotides. Exhibites a single-stranded DNA-dependent ATPase activity. Could be involved in the repair of interstrand cross-links.<ref>PMID:14576298</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: DNA-directed DNA polymerase]] | |||
[[Category: Aitkenhead, H]] | [[Category: Aitkenhead, H]] | ||
[[Category: | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
[[Category: Burgess-Brown, N]] | |||
[[Category: Cooper, C D.O]] | |||
[[Category: Delft, F von]] | |||
[[Category: Edwards, A]] | |||
[[Category: Gileadi, O]] | |||
[[Category: Kupinska, K]] | [[Category: Kupinska, K]] | ||
[[Category: | [[Category: Newman, J A]] | ||
[[Category: | [[Category: Pinkas, D M]] | ||
[[Category: Dna repair]] | |||
[[Category: | [[Category: Polq]] | ||
[[Category: | [[Category: Transferase]] | ||
[[Category: | |||
Revision as of 14:07, 25 February 2015
Crystal structure of the Helicase domain of human DNA polymerase theta in complex with AMPPNP
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