4qtf: Difference between revisions
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''' | ==Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation== | ||
<StructureSection load='4qtf' size='340' side='right' caption='[[4qtf]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4qtf]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4QTF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4QTF FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=3V5:(3S,5S)-3-({[(AMINOMETHYL)AMINO]METHYL}SULFANYL)-5-[(2S)-1,3-DIOXOBUTAN-2-YL]-L-PROLINE'>3V5</scene>, <scene name='pdbligand=MLD:GLCNAC(BETA1-4)-MURNAC(1,6-ANHYDRO)-L-ALA-GAMMA-D-GLU-MESO-A2PM-D-ALA'>MLD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4qtf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4qtf OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4qtf RCSB], [http://www.ebi.ac.uk/pdbsum/4qtf PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[Category: | [[http://www.uniprot.org/uniprot/LDT2_MYCTU LDT2_MYCTU]] Generates 3->3 cross-links in peptidoglycan, catalyzing the cleavage of the mDap(3)-D-Ala(4) bond of a tetrapeptide donor stem and the formation of a bond between the carbonyl of mDap(3) of the donor stem and the side chain of mDap(3) of the acceptor stem. Is specific for donor substrates containing a stem tetrapeptide since it cannot use pentapeptide stems.<ref>PMID:24041897</ref> | ||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Structural genomic]] | |||
[[Category: Gokulan, K]] | [[Category: Gokulan, K]] | ||
[[Category: | [[Category: Varughese, K I]] | ||
[[Category: Beta-lactamase]] | |||
[[Category: Cross-linkage]] | |||
[[Category: Csgid]] | |||
[[Category: D-d-transpeptidase]] | |||
[[Category: Enzyme function initiative]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Imipenem]] | |||
[[Category: L-d-transpeptidase]] | |||
[[Category: Meropenem]] | |||
[[Category: Peptidoglycan]] | |||
Revision as of 14:46, 29 July 2015
Structure and specificity of L-D-Transpeptidase from Mycobacterium tuberculosis and antibiotic resistance: Calcium binding promotes dimer formation
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