4xnw: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==The human P2Y1 receptor in complex with MRS2500==

~~The entry~~ 4xnw is ~~ON HOLD~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4xnw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XNW OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XNW FirstGlance].

~~Authors~~: Wu, B., ~~Zhao~~, Q., ~~Zhang~~, D., ~~Gao~~, Z., ~~Jacobson~~, K., Han, G.W~~., Stevens, R.~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2ID:[(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEX-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2ID</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4xnv|4xnv]]</td></tr>

~~Description~~: ~~The human P2Y1 receptor~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xnw RCSB], [http://www.ebi.ac.uk/pdbsum/4xnw PDBsum]</td></tr>

[[Category: ~~Unreleased Structures~~]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/P2RY1_HUMAN P2RY1_HUMAN]] Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref>PMID:9442040</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Gao, Z]]

[[Category: Han, G W]]

[[Category: Jacobson, K]]

[[Category: Stevens, R]]

[[Category: Wu, B]]

~~[[Category: Stevens, R]]~~

~~[[Category: Gao, Z]]~~

~~[[Category: Han, G.W]]~~

[[Category: Zhang, D]]

~~[[Category: Jacobson, K]]~~

[[Category: Zhao, Q]]

[[Category: G protein coupled receptor]]

[[Category: Human p2y1 receptor]]

[[Category: Membrane protein]]

[[Category: Platelet activation]]

[[Category: Transport protein]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==The human P2Y1 receptor in complex with MRS2500==
+<StructureSection load='4xnw' size='340' side='right' caption='[[4xnw]], [[Resolution|resolution]] 2.70&Aring;' scene=''>
-The entry 4xnw is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4xnw]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XNW OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XNW FirstGlance]. <br>
-Authors: Wu, B., Zhao, Q., Zhang, D., Gao, Z., Jacobson, K., Han, G.W., Stevens, R.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2ID:[(1R,2S,4S,5S)-4-[2-IODO-6-(METHYLAMINO)-9H-PURIN-9-YL]-2-(PHOSPHONOOXY)BICYCLO[3.1.0]HEX-1-YL]METHYL+DIHYDROGEN+PHOSPHATE'>2ID</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xnv|4xnv]]</td></tr>
-Description: The human P2Y1 receptor
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xnw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xnw OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xnw RCSB], [http://www.ebi.ac.uk/pdbsum/4xnw PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/P2RY1_HUMAN P2RY1_HUMAN]] Receptor for extracellular adenine nucleotides such as ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation.<ref>PMID:9442040</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Gao, Z]]
+[[Category: Han, G W]]
+[[Category: Jacobson, K]]
+[[Category: Stevens, R]]
 [[Category: Wu, B]]
-[[Category: Stevens, R]]
-[[Category: Gao, Z]]
-[[Category: Han, G.W]]
 [[Category: Zhang, D]]
-[[Category: Jacobson, K]]
 [[Category: Zhao, Q]]
+[[Category: G protein coupled receptor]]
+[[Category: Human p2y1 receptor]]
+[[Category: Membrane protein]]
+[[Category: Platelet activation]]
+[[Category: Transport protein]]