4pqe: Difference between revisions

Revision as of 11:13, 8 April 2015

Crystal Structure of Human Acetylcholinesterase

Proteopedia Page Contributors and Editors (what is this?)

OCA, Joel L. Sussman

[1] Chhajlani V, Derr D, Earles B, Schmell E, August T. Purification and partial amino acid sequence analysis of human erythrocyte acetylcholinesterase. FEBS Lett. 1989 Apr 24;247(2):279-82. PMID:2714437

[2] Velan B, Grosfeld H, Kronman C, Leitner M, Gozes Y, Lazar A, Flashner Y, Marcus D, Cohen S, Shafferman A. The effect of elimination of intersubunit disulfide bonds on the activity, assembly, and secretion of recombinant human acetylcholinesterase. Expression of acetylcholinesterase Cys-580----Ala mutant. J Biol Chem. 1991 Dec 15;266(35):23977-84. PMID:1748670

[3] Shafferman A, Kronman C, Flashner Y, Leitner M, Grosfeld H, Ordentlich A, Gozes Y, Cohen S, Ariel N, Barak D, et al.. Mutagenesis of human acetylcholinesterase. Identification of residues involved in catalytic activity and in polypeptide folding. J Biol Chem. 1992 Sep 5;267(25):17640-8. PMID:1517212

[4] Yang L, He HY, Zhang XJ. Increased expression of intranuclear AChE involved in apoptosis of SK-N-SH cells. Neurosci Res. 2002 Apr;42(4):261-8. PMID:11985878

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-'''Unreleased structure'''
+==Crystal Structure of Human Acetylcholinesterase==
+<StructureSection load='4pqe' size='340' side='right' caption='[[4pqe]], [[Resolution|resolution]] 2.90&Aring;' scene=''>
-The entry 4pqe is ON HOLD
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4pqe]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4PQE OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4PQE FirstGlance]. <br>
-Authors: Dym, O., Unger, T., Toker, L., Silman, I., Sussman, J.L., Israel Structural Proteomics Center (ISPC)
+</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lii|3lii]], [[4ey4|4ey4]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Acetylcholinesterase Acetylcholinesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.1.7 3.1.1.7] </span></td></tr>
-Description: Crystal Structure of Human Acetylcholinesterase
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4pqe FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4pqe OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4pqe RCSB], [http://www.ebi.ac.uk/pdbsum/4pqe PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Israel Structural Proteomics Center (Ispc)]]
+== Function ==
+[[http://www.uniprot.org/uniprot/ACES_HUMAN ACES_HUMAN]] Terminates signal transduction at the neuromuscular junction by rapid hydrolysis of the acetylcholine released into the synaptic cleft. Role in neuronal apoptosis.<ref>PMID:2714437</ref> <ref>PMID:1748670</ref> <ref>PMID:1517212</ref> <ref>PMID:11985878</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Acetylcholinesterase]]
+[[Category: Dym, O]]
+[[Category: ISPC, Israel Structural Proteomics Center]]
+[[Category: Silman, I]]
+[[Category: Sussman, J L]]
+[[Category: Toker, L]]
 [[Category: Unger, T]]
-[[Category: Sussman, J.L]]
+[[Category: Alpha/beta hydrolase]]
-[[Category: Toker, L]]
+[[Category: Hydrolase]]
-[[Category: Silman, I]]
+[[Category: Structural genomic]]
-[[Category: Dym, O]]

4pqe: Difference between revisions

Revision as of 11:13, 8 April 2015

Crystal Structure of Human Acetylcholinesterase

Structural highlights

Function

References

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