4xi6: Difference between revisions
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''' | ==Crystal structure of the MZM-REP domains of Mind bomb 1== | ||
<StructureSection load='4xi6' size='340' side='right' caption='[[4xi6]], [[Resolution|resolution]] 2.04Å' scene=''> | |||
The entry | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4xi6]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4XI6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4XI6 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4xi7|4xi7]], [[4xib|4xib]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4xi6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4xi6 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4xi6 RCSB], [http://www.ebi.ac.uk/pdbsum/4xi6 PDBsum]</span></td></tr> | |||
[[Category: | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [[http://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN]] Left ventricular noncompaction. The disease is caused by mutations affecting the gene represented in this entry. | ||
== Function == | |||
[[http://www.uniprot.org/uniprot/MIB1_HUMAN MIB1_HUMAN]] E3 ubiquitin-protein ligase that mediates ubiquitination of Delta receptors, which act as ligands of Notch proteins. Positively regulates the Delta-mediated Notch signaling by ubiquitinating the intracellular domain of Delta, leading to endocytosis of Delta receptors. Probably mediates ubiquitination and subsequent proteasomal degradation of DAPK1, thereby antagonizing anti-apoptotic effects of DAPK1 to promote TNF-induced apoptosis (By similarity). Involved in ubiquitination of centriolar satellite CEP131, CEP290 and PCM1 proteins and hence inhibits primary cilium formation in proliferating cells. Mediates 'Lys-63'-linked polyubiquitination of TBK1, which probably participates in kinase activation.<ref>PMID:24121310</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Blacklow, S C]] | |||
[[Category: McMillan, B J]] | |||
[[Category: E3 ligase]] | |||
[[Category: Ligase]] | |||
[[Category: Notch signaling]] | |||
Revision as of 12:17, 18 March 2015
Crystal structure of the MZM-REP domains of Mind bomb 1
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