2q1b: Difference between revisions

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|PDB= 2q1b |SIZE=350|CAPTION= <scene name='initialview01'>2q1b</scene>, resolution 1.70&Aring;
|PDB= 2q1b |SIZE=350|CAPTION= <scene name='initialview01'>2q1b</scene>, resolution 1.70&Aring;
|SITE=  
|SITE=  
|LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene> and <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE 1,1-DIOXIDE'>LSA</scene>
|LIGAND= <scene name='pdbligand=BEZ:BENZOIC+ACID'>BEZ</scene>, <scene name='pdbligand=HG:MERCURY+(II)+ION'>HG</scene>, <scene name='pdbligand=LSA:1,2-BENZISOTHIAZOL-3(2H)-ONE+1,1-DIOXIDE'>LSA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene>
|ACTIVITY= [http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1]  
|ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carbonate_dehydratase Carbonate dehydratase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=4.2.1.1 4.2.1.1] </span>
|GENE=  
|GENE=  
|DOMAIN=
|RELATEDENTRY=[[1oq5|1oq5]], [[1z9y|1z9y]]
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2q1b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2q1b OCA], [http://www.ebi.ac.uk/pdbsum/2q1b PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2q1b RCSB]</span>
}}
}}


'''Carbonic Anhydrase II in Complex with Saccharin'''
'''Carbonic Anhydrase II in Complex with Saccharin'''


==Disease==
Known disease associated with this structure: Osteopetrosis, autosomal recessive 3, with renal tubular acidosis OMIM:[[http://www.ncbi.nlm.nih.gov/entrez/dispomim.cgi?id=611492 611492]]


==About this Structure==
==About this Structure==
Line 26: Line 26:
[[Category: Klebe, G.]]
[[Category: Klebe, G.]]
[[Category: Koehler, K.]]
[[Category: Koehler, K.]]
[[Category: BEZ]]
[[Category: HG]]
[[Category: LSA]]
[[Category: ZN]]
[[Category: 10-stranded]]
[[Category: 10-stranded]]
[[Category: lyase]]
[[Category: lyase]]
[[Category: twisted beta-sheet]]
[[Category: twisted beta-sheet]]


''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 18:20:30 2008''
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:43:26 2008''

Revision as of 01:43, 31 March 2008

File:2q1b.jpg


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2q1b, resolution 1.70Å
Ligands: BEZ, HG, LSA, ZN
Activity: Carbonate dehydratase, with EC number 4.2.1.1
Related: 1oq5, 1z9y


Resources: FirstGlance, OCA, PDBsum, RCSB
Coordinates: save as pdb, mmCIF, xml



Carbonic Anhydrase II in Complex with Saccharin


About this Structure

2Q1B is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Saccharin inhibits carbonic anhydrases: possible explanation for its unpleasant metallic aftertaste., Kohler K, Hillebrecht A, Schulze Wischeler J, Innocenti A, Heine A, Supuran CT, Klebe G, Angew Chem Int Ed Engl. 2007;46(40):7697-9. PMID:17705204

Page seeded by OCA on Mon Mar 31 04:43:26 2008

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