Sandbox Reserved 994: Difference between revisions
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Josie Werner (talk | contribs) No edit summary |
Josie Werner (talk | contribs) No edit summary |
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The mechanism of attack involves a catalytic serine residue, a carboxylated lysine, and another active site serine which contributes to proton movement (A). A high energy tetrahedral intermediate (B) is generated and an acyl enzyme intermediate (C) is formed after the cleavage of the four-membered ring. KCX84 activates the deacylating water which completes the reaction leaving a hydrolyzed β-lactam ring and a regenerated β-lactamase (Powers paper 2013). | The mechanism of attack involves a catalytic serine residue, a carboxylated lysine, and another active site serine which contributes to proton movement (A). A high energy tetrahedral intermediate (B) is generated and an acyl enzyme intermediate (C) is formed after the cleavage of the four-membered ring. KCX84 activates the deacylating water which completes the reaction leaving a hydrolyzed β-lactam ring and a regenerated β-lactamase (Powers paper 2013). | ||
<scene name='69/691536/Closeupdrug/1'>close up</scene> | <scene name='69/691536/Closeupdrug/1'>close up</scene><ref>PMID: 10817708</ref> | ||
== Inhibition == | == Inhibition == | ||
