Sandbox Reserved 994: Difference between revisions

Revision as of 20:35, 21 February 2015 view source Josie Werner (talk \| contribs) 62 edits No edit summary ← Older edit		Revision as of 20:50, 21 February 2015 view source Josie Werner (talk \| contribs) 62 edits No edit summary Newer edit →
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	[[Image:Beta-lactamase resized mechanism.png\|500px\|left\|thumb\|alt=text\|The mechanism of attack involves a catalytic serine residue, a carboxylated lysine, and another active site serine which contributes to proton movement (A). A high energy tetrahedral intermediate (B) is generated and an acyl enzyme intermediate (C) is formed after the cleavage of the four-membered ring. KCX84 activates the deacylating water which completes the reaction leaving a hydrolyzed β-lactam ring and a regenerated β-lactamase.<ref>DOI: 10.1021/ar300327a</ref>]]		[[Image:Beta-lactamase resized mechanism.png\|500px\|left\|thumb\|alt=text\|The mechanism of attack involves a catalytic serine residue, a carboxylated lysine, and another active site serine which contributes to proton movement (A). A high energy tetrahedral intermediate (B) is generated and an acyl enzyme intermediate (C) is formed after the cleavage of the four-membered ring. KCX84 activates the deacylating water which completes the reaction leaving a hydrolyzed β-lactam ring and a regenerated β-lactamase.<ref>DOI: 10.1021/ar300327a</ref>]]

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