Sandbox Reserved 995: Difference between revisions

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== HEAT Repeat Motif ==

PP2A belongs in the HEAT Repeat Motif or Huntington-elongation-A subunit-TOR. The main backbone of PP2A are 15 repeating units or <~~scenename~~='69/691537/Heat/1'>HEAT units</scene>, each composed of a conserved 39-residue sequence.The HEAT Motif has a signature sequence of conserved residues asparagine at position 19 and arginine at position 25. Each HEAT unit consists of a pair of antiparallel alpha-helices. These antiparallel helices assemble in a L-shaped fashion resulting in an overall shape of a double layer of alpha helices. These HEAT units are responsible for a majority of the overall protein packing and structure by interactions of the ridges of each HEAT unit.

PP2A belongs in the HEAT Repeat Motif or Huntington-elongation-A subunit-TOR. The main backbone of PP2A are 15 repeating units or <scene name='69/691537/Heat/1'>HEAT units</scene>, each composed of a conserved 39-residue sequence.The HEAT Motif has a signature sequence of conserved residues asparagine at position 19 and arginine at position 25. Each HEAT unit consists of a pair of antiparallel alpha-helices. These antiparallel helices assemble in a L-shaped fashion resulting in an overall shape of a double layer of alpha helices. These HEAT units are responsible for a majority of the overall protein packing and structure by interactions of the ridges of each HEAT unit.

== Huntington's Disease ==

Sandbox Reserved 995: Difference between revisions

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 == HEAT Repeat Motif ==
-PP2A belongs in the HEAT Repeat Motif or Huntington-elongation-A subunit-TOR. The main backbone of PP2A are 15 repeating units or <scenename='69/691537/Heat/1'>HEAT units</scene>, each composed of a conserved 39-residue sequence.The HEAT Motif has a signature sequence of conserved residues asparagine at position 19 and arginine at position 25.  Each HEAT unit consists of a pair of antiparallel alpha-helices. These antiparallel helices assemble in a L-shaped fashion resulting in an overall shape of a double layer of alpha helices.  These HEAT units are responsible for a majority of the overall protein packing and structure by interactions of the ridges of each HEAT unit.
+PP2A belongs in the HEAT Repeat Motif or Huntington-elongation-A subunit-TOR. The main backbone of PP2A are 15 repeating units or <scene name='69/691537/Heat/1'>HEAT units</scene>, each composed of a conserved 39-residue sequence.The HEAT Motif has a signature sequence of conserved residues asparagine at position 19 and arginine at position 25.  Each HEAT unit consists of a pair of antiparallel alpha-helices. These antiparallel helices assemble in a L-shaped fashion resulting in an overall shape of a double layer of alpha helices.  These HEAT units are responsible for a majority of the overall protein packing and structure by interactions of the ridges of each HEAT unit.
 == Huntington's Disease ==