4y1t: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes==

~~The entry~~ 4y1t is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4y1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y1T OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y1T FirstGlance].

~~Authors~~: ~~Conroy~~, P.J., ~~Yagi, H~~.~~, Whisstock, J~~.C., ~~Norton, R~~.S.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[4y1s|4y1s]]</td></tr>

~~Description: Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y1t RCSB], [http://www.ebi.ac.uk/pdbsum/4y1t PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures~~]]

</table>

[[Category: Conroy, P.J]]

== Function ==

[[Category: Norton, R.S]]

[[http://www.uniprot.org/uniprot/PERF_MOUSE PERF_MOUSE]] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.<ref>PMID:3261391</ref> <ref>PMID:8164737</ref> <ref>PMID:7526382</ref> <ref>PMID:19446473</ref> <ref>PMID:21037563</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Conroy, P J]]

[[Category: Norton, R S]]

[[Category: Whisstock, J C]]

[[Category: Yagi, H]]

[[Category: ~~Whisstock, J.C~~]]

[[Category: C2 domain]]

[[Category: Calcium binding]]

[[Category: Immune system]]

[[Category: Perforin]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes==
+<StructureSection load='4y1t' size='340' side='right' caption='[[4y1t]], [[Resolution|resolution]] 2.67&Aring;' scene=''>
-The entry 4y1t is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4y1t]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y1T OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y1T FirstGlance]. <br>
-Authors: Conroy, P.J., Yagi, H., Whisstock, J.C., Norton, R.S.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4y1s|4y1s]]</td></tr>
-Description: Structural basis for Ca2+-mediated interaction of the perforin C2 domain with lipid membranes
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y1t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y1t OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y1t RCSB], [http://www.ebi.ac.uk/pdbsum/4y1t PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Conroy, P.J]]
+== Function ==
-[[Category: Norton, R.S]]
+[[http://www.uniprot.org/uniprot/PERF_MOUSE PERF_MOUSE]] Plays a key role in secretory granule-dependent cell death, and in defense against virus-infected or neoplastic cells. Can insert into the membrane of target cells in its calcium-bound form, oligomerize and form large pores. Promotes cytolysis and apoptosis of target cells by facilitating the uptake of cytotoxic granzymes.<ref>PMID:3261391</ref> <ref>PMID:8164737</ref> <ref>PMID:7526382</ref> <ref>PMID:19446473</ref> <ref>PMID:21037563</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Conroy, P J]]
+[[Category: Norton, R S]]
+[[Category: Whisstock, J C]]
 [[Category: Yagi, H]]
-[[Category: Whisstock, J.C]]
+[[Category: C2 domain]]
+[[Category: Calcium binding]]
+[[Category: Immune system]]
+[[Category: Perforin]]