4y2b: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A==

~~The entry~~ 4y2b is ~~ON HOLD until Feb 09 2017~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4y2b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2B OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y2B FirstGlance].

~~Authors~~: ~~Endo, Y~~.~~, Kawai, K~~.~~, Asano, T~~.~~, Amano, S~~.~~, Asanuma, Y~~.~~, Sawada, K~~.~~, Onodera, Y~~.~~, Ueo, N~~.~~, Takahashi, N., Sonoda, Y., Kamei, N., Irie, T~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=EPK:3-ETHYL-2-(PROPAN-2-YLAMINO)-7-(PYRIDIN-3-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE'>EPK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </td></tr>

~~Description~~: ~~Co-crystal structure of~~ 3-~~ethyl~~-2-(~~isopropylamino~~)-7-(~~pyridin~~-3-yl)~~thieno~~[3,2-d]~~pyrimidin~~-4(3H)-~~one bound to PDE7A~~

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y2b RCSB], [http://www.ebi.ac.uk/pdbsum/4y2b PDBsum]</td></tr>

[[~~Category~~: ~~Unreleased Structures]~~]

</table>

[[~~Category~~: ~~Kawai~~, K]]

== Function ==

[~~[Category~~: ~~Ueo, N]~~]

[[http://www.uniprot.org/uniprot/PDE7A_HUMAN PDE7A_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.<ref>PMID:19350606</ref>

[[~~Category~~: ~~Kamei, N~~]]

== References ==

[[Category: ~~Sonoda~~, Y]]

__TOC__

</StructureSection>

[[Category: 3',5'-cyclic-AMP phosphodiesterase]]

[[Category: Amano, S]]

[[Category: ~~Onodera, Y]]~~

[[Category: Asano, T]]

~~[[Category: Irie~~, T]]

~~[[Category: Takahashi, N~~]]

[[Category: Asanuma, Y]]

~~[[Category: Asano, T]]~~

[[Category: Endo, Y]]

[[Category: Irie, T]]

[[Category: Kamei, N]]

[[Category: Kawai, K]]

[[Category: Onodera, Y]]

[[Category: Sawada, K]]

[[Category: Sonoda, Y]]

[[Category: Takahashi, N]]

[[Category: Ueo, N]]

[[Category: Camp]]

[[Category: Hydrolase-hydrolase inhibitor complex]]

[[Category: Pde7a]]

[[Category: Phosphodiesterase]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A==
+<StructureSection load='4y2b' size='340' side='right' caption='[[4y2b]], [[Resolution|resolution]] 2.20&Aring;' scene=''>
-The entry 4y2b is ON HOLD  until Feb 09 2017
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4y2b]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y2B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y2B FirstGlance]. <br>
-Authors: Endo, Y., Kawai, K., Asano, T., Amano, S., Asanuma, Y., Sawada, K., Onodera, Y., Ueo, N., Takahashi, N., Sonoda, Y., Kamei, N., Irie, T.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPK:3-ETHYL-2-(PROPAN-2-YLAMINO)-7-(PYRIDIN-3-YL)THIENO[3,2-D]PYRIMIDIN-4(3H)-ONE'>EPK</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/3',5'-cyclic-AMP_phosphodiesterase 3',5'-cyclic-AMP phosphodiesterase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.1.4.53 3.1.4.53] </span></td></tr>
-Description: Co-crystal structure of 3-ethyl-2-(isopropylamino)-7-(pyridin-3-yl)thieno[3,2-d]pyrimidin-4(3H)-one bound to PDE7A
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y2b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y2b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y2b RCSB], [http://www.ebi.ac.uk/pdbsum/4y2b PDBsum]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Kawai, K]]
+== Function ==
-[[Category: Ueo, N]]
+[[http://www.uniprot.org/uniprot/PDE7A_HUMAN PDE7A_HUMAN]] Hydrolyzes the second messenger cAMP, which is a key regulator of many important physiological processes. May have a role in muscle signal transduction.<ref>PMID:19350606</ref>
-[[Category: Kamei, N]]
+== References ==
-[[Category: Sonoda, Y]]
+<references/>
+__TOC__
+</StructureSection>
+[[Category: 3',5'-cyclic-AMP phosphodiesterase]]
 [[Category: Amano, S]]
-[[Category: Onodera, Y]]
+[[Category: Asano, T]]
-[[Category: Irie, T]]
-[[Category: Takahashi, N]]
 [[Category: Asanuma, Y]]
-[[Category: Asano, T]]
 [[Category: Endo, Y]]
+[[Category: Irie, T]]
+[[Category: Kamei, N]]
+[[Category: Kawai, K]]
+[[Category: Onodera, Y]]
 [[Category: Sawada, K]]
+[[Category: Sonoda, Y]]
+[[Category: Takahashi, N]]
+[[Category: Ueo, N]]
+[[Category: Camp]]
+[[Category: Hydrolase-hydrolase inhibitor complex]]
+[[Category: Pde7a]]
+[[Category: Phosphodiesterase]]