4y5o: Difference between revisions
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''' | ==CCM2 HHD in complex with MEKK3 NPB1== | ||
<StructureSection load='4y5o' size='340' side='right' caption='[[4y5o]], [[Resolution|resolution]] 2.35Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4y5o]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Y5O OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Y5O FirstGlance]. <br> | |||
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Mitogen-activated_protein_kinase_kinase_kinase Mitogen-activated protein kinase kinase kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.25 2.7.11.25] </span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4y5o FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4y5o OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4y5o RCSB], [http://www.ebi.ac.uk/pdbsum/4y5o PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Disease == | ||
[[Category: Fisher, O | [[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Hereditary cerebral cavernous malformation. The disease is caused by mutations affecting the gene represented in this entry. | ||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/CCM2_HUMAN CCM2_HUMAN]] Component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions (By similarity). May function as a scaffold protein for MAP2K3-MAP3K3 signaling. Seems to play a major role in the modulation of MAP3K3-dependent p38 activation induced by hyperosmotic shock (By similarity). [[http://www.uniprot.org/uniprot/M3K3_HUMAN M3K3_HUMAN]] Component of a protein kinase signal transduction cascade. Mediates activation of the NF-kappa-B, AP1 and DDIT3 transcriptional regulators.<ref>PMID:9006902</ref> <ref>PMID:12912994</ref> <ref>PMID:14661019</ref> <ref>PMID:14743216</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Mitogen-activated protein kinase kinase kinase]] | |||
[[Category: Boggon, T J]] | |||
[[Category: Fisher, O S]] | |||
[[Category: Complex]] | |||
[[Category: Kinase]] | |||
[[Category: Scaffold]] | |||
[[Category: Transferase]] | |||
Revision as of 12:24, 1 July 2015
CCM2 HHD in complex with MEKK3 NPB1
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