UBC13 MMS2: Difference between revisions
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==Summary== | ==Summary== | ||
Ubc13 is an E2 ubiquitin conjugating enzyme that can form a heterodimer with Mms2 to function as a part of the Translesion DNA Synthesis Pathway (TLS). When bound to Mms2, Ubc13 will | Ubc13 is an E2 ubiquitin conjugating enzyme that can form a heterodimer with Mms2 to function as a part of the Translesion DNA Synthesis Pathway (TLS). When bound to Mms2, Ubc13 will polyubiquitinate proliferating cell nuclear antigen (PCNA), a sliding clamp protein at the DNA transcription fork. Ubc13-Mms2 functions to polyubiquitinate PCNA following the initial monoubiquitination by Rad6-Rad18(another E2 complex). | ||
== Function == | == Function == | ||
