Sandbox Reserved 994: Difference between revisions

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== Background ==

OXA-24 is a member of the carbapenem-hydrolyzing class D β-lactamases (CHDLs), and is expressed as a resistance mechanism by the bacteria, Acinetobacter baumannii. Class D β-lactamases are clinically dangerous because they hydrolyze β-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems. Class D β-lactamases are classified as OXA’s, in reference to their class designation as oxacillinases. The terminology is somewhat misleading; while they do have very strong affinity for the antibiotic oxacillin<ref>DOI: 10.1021/ar300327a</ref>, the OXA’s have expanded since their discovery to include penillinase, cephalosporinase, and carbapenemase activity in their spectrum. However, due to their original designation as oxacillinases, the assignment of the prefix OXA has continued to be standard designation.

OXA-24 is a member of the carbapenem-hydrolyzing class D β-lactamases (CHDLs), and is expressed as a resistance mechanism by the bacteria, Acinetobacter baumannii. Class D β-lactamases are clinically dangerous because they hydrolyze β-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems. Class D β-lactamases are classified as OXA’s, in reference to their class designation as oxacillinases. The terminology is somewhat misleading; while they do have very strong affinity for the antibiotic oxacillin<ref name="Leonard">DOI: 10.1021/ar300327a</ref>, the OXA’s have expanded since their discovery to include penillinase, cephalosporinase, and carbapenemase activity in their spectrum. However, due to their original designation as oxacillinases, the assignment of the prefix OXA has continued to be standard designation.

== Bacterial Resistance ==

Sandbox Reserved 994: Difference between revisions

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 == Background ==
-OXA-24 is a member of the carbapenem-hydrolyzing class D β-lactamases (CHDLs), and is expressed as a resistance mechanism by the bacteria, Acinetobacter baumannii. Class D β-lactamases are clinically dangerous because they hydrolyze β-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems. Class D β-lactamases are classified as OXA’s, in reference to their class designation as oxacillinases. The terminology is somewhat misleading; while they do have very strong affinity for the antibiotic oxacillin<ref>DOI: 10.1021/ar300327a</ref>, the OXA’s have expanded since their discovery to include penillinase, cephalosporinase, and carbapenemase activity in their spectrum. However, due to their original designation as oxacillinases, the assignment of the prefix OXA has continued to be standard designation.
+OXA-24 is a member of the carbapenem-hydrolyzing class D β-lactamases (CHDLs), and is expressed as a resistance mechanism by the bacteria, Acinetobacter baumannii. Class D β-lactamases are clinically dangerous because they hydrolyze β-lactam antibiotics, such as penicillins, cephalosporins, and carbapenems. Class D β-lactamases are classified as OXA’s, in reference to their class designation as oxacillinases. The terminology is somewhat misleading; while they do have very strong affinity for the antibiotic oxacillin<ref name="Leonard">DOI: 10.1021/ar300327a</ref>, the OXA’s have expanded since their discovery to include penillinase, cephalosporinase, and carbapenemase activity in their spectrum. However, due to their original designation as oxacillinases, the assignment of the prefix OXA has continued to be standard designation.
 == Bacterial Resistance ==