Sandbox Reserved 992: Difference between revisions

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== Clinical Significance ==

Since the discovery of penicillin in the late 1920s, β-lactam antibiotics, characterized by their central chemical structure, the β-lactam ring, have played an important role in human health. Unfortunately, extensive use, and often misuse, of such drugs has led to an increased resistance in many species of bacterium resulting in major clinical treatment dilemmas. Each year in the United States alone, a minimum of 2 million people are infected with drug-resistant bacteria and of those 2 million, at least 23,000 infections result in fatality.<ref>Antibiotic Resistant Threat Report in the United States, 2013. Centers for Disease Control and Prevention. 16 September, 2013.</ref> Fortunately, fiscal year funding for antibiotic resistance research from the U.S. government has nearly to $1.2 billion, providing a more optimistic outlook for this serious issue in clinical treatment.<ref>ASM Statement on the President’s Proposed 2016 Budget to Combat Antibiotic-resistant Bacteria. American Society for Microbiology. 28 Jan 2015. Web. 22 Feb 2015.</ref>

Since the discovery of penicillin in the late 1920s by [http://en.m.wikipedia.org/wiki/Alexander_Flemming Alexander Flemming] β-lactam antibiotics, characterized by their central chemical structure, the β-lactam ring, have played an important role in human health. Unfortunately, extensive use, and often misuse, of such drugs has led to an increased resistance in many species of bacterium resulting in major clinical treatment dilemmas. Each year in the United States alone, a minimum of 2 million people are infected with drug-resistant bacteria and of those 2 million, at least 23,000 infections result in fatality.<ref>Antibiotic Resistant Threat Report in the United States, 2013. Centers for Disease Control and Prevention. 16 September, 2013.</ref> Fortunately, fiscal year funding for antibiotic resistance research from the U.S. government has nearly to $1.2 billion, providing a more optimistic outlook for this serious issue in clinical treatment.<ref>ASM Statement on the President’s Proposed 2016 Budget to Combat Antibiotic-resistant Bacteria. American Society for Microbiology. 28 Jan 2015. Web. 22 Feb 2015.</ref>

== Class C Inhibition ==

Sandbox Reserved 992: Difference between revisions

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 == Clinical Significance ==
-Since the discovery of penicillin in the late 1920s, β-lactam antibiotics, characterized by their central chemical structure, the β-lactam ring, have played an important role in human health. Unfortunately, extensive use, and often misuse, of such drugs has led to an increased resistance in many species of bacterium resulting in major clinical treatment dilemmas.  Each year in the United States alone, a minimum of 2 million people are infected with drug-resistant bacteria and of those 2 million, at least 23,000 infections result in fatality.<ref>Antibiotic Resistant Threat Report in the United States, 2013. Centers for Disease Control and Prevention. 16 September, 2013.</ref> Fortunately, fiscal year funding for antibiotic resistance research from the U.S. government has nearly to $1.2 billion, providing a more optimistic outlook for this serious issue in clinical treatment.<ref>ASM Statement on the President’s Proposed 2016 Budget to Combat Antibiotic-resistant Bacteria. American Society for Microbiology. 28 Jan 2015. Web. 22 Feb 2015.</ref>
+Since the discovery of penicillin in the late 1920s by [http://en.m.wikipedia.org/wiki/Alexander_Flemming Alexander Flemming] β-lactam antibiotics, characterized by their central chemical structure, the β-lactam ring, have played an important role in human health. Unfortunately, extensive use, and often misuse, of such drugs has led to an increased resistance in many species of bacterium resulting in major clinical treatment dilemmas.  Each year in the United States alone, a minimum of 2 million people are infected with drug-resistant bacteria and of those 2 million, at least 23,000 infections result in fatality.<ref>Antibiotic Resistant Threat Report in the United States, 2013. Centers for Disease Control and Prevention. 16 September, 2013.</ref> Fortunately, fiscal year funding for antibiotic resistance research from the U.S. government has nearly to $1.2 billion, providing a more optimistic outlook for this serious issue in clinical treatment.<ref>ASM Statement on the President’s Proposed 2016 Budget to Combat Antibiotic-resistant Bacteria. American Society for Microbiology. 28 Jan 2015. Web. 22 Feb 2015.</ref>
 == Class C Inhibition ==