4yea: Difference between revisions
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''' | ==Crystal structure of cisplatin bound to a human copper chaperone (dimer) - new refinement== | ||
<StructureSection load='4yea' size='340' side='right' caption='[[4yea]], [[Resolution|resolution]] 2.14Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yea]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YEA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YEA FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CU:COPPER+(II)+ION'>CU</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3iwx|3iwx]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yea FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yea OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yea RCSB], [http://www.ebi.ac.uk/pdbsum/4yea PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/ATOX1_HUMAN ATOX1_HUMAN]] Binds and deliver cytosolic copper to the copper ATPase proteins. May be important in cellular antioxidant defense. | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Copper trafficking proteins, including the chaperone Atox1 and the P(1B)-type ATPase ATP7B, have been implicated in cellular resistance to the anticancer drug cisplatin. We have determined two crystal structures of cisplatin-Atox1 adducts that reveal platinum coordination by the conserved CXXC copper-binding motif. Direct interaction of cisplatin with this functionally relevant site has significant implications for understanding the molecular basis for resistance mediated by copper transport pathways. | |||
Crystal structures of cisplatin bound to a human copper chaperone.,Boal AK, Rosenzweig AC J Am Chem Soc. 2009 Oct 14;131(40):14196-7. PMID:19807176<ref>PMID:19807176</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
</div> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Dauter, Z]] | [[Category: Dauter, Z]] | ||
[[Category: | [[Category: Jaskolski, M]] | ||
[[Category: Minor, W]] | |||
[[Category: Shabalin, I G]] | |||
[[Category: Wlodawer, A]] | [[Category: Wlodawer, A]] | ||
[[Category: | [[Category: Cisplatin]] | ||
[[Category: | [[Category: Metal transport]] | ||
[[Category: | [[Category: Metal-binding]] | ||
[[Category: | [[Category: Platinum]] | ||
[[Category: Re-refinement of 3iwx]] | |||
Revision as of 11:59, 18 March 2015
Crystal structure of cisplatin bound to a human copper chaperone (dimer) - new refinement
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