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'''Unreleased structure'''
==Escherichia coli RNA polymerase in complex with Myxopyronin B==
 
<StructureSection load='4yfx' size='340' side='right' caption='[[4yfx]], [[Resolution|resolution]] 3.84&Aring;' scene=''>
The entry 4yfx is ON HOLD
== Structural highlights ==
 
<table><tr><td colspan='2'>[[4yfx]] is a 12 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YFX OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YFX FirstGlance]. <br>
Authors: Molodtsov, V., Fleming, P.R., Eyermann, C.J., Ferguson, A.D., Foulk, M.A., McKinney, D.C., Masse, C.E., Buurman, E.T., Murakami, K.S.
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4C4:MYXOPYRONIN+B'>4C4</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
 
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yfk|4yfk]], [[4yfn|4yfn]]</td></tr>
Description: Escherichia coli RNA polymerase in complex with squaramide compound 8.
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/DNA-directed_RNA_polymerase DNA-directed RNA polymerase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.6 2.7.7.6] </span></td></tr>
[[Category: Unreleased Structures]]
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yfx FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yfx OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yfx RCSB], [http://www.ebi.ac.uk/pdbsum/4yfx PDBsum]</span></td></tr>
[[Category: Mckinney, D.C]]
</table>
[[Category: Buurman, E.T]]
== Function ==
[[Category: Eyermann, C.J]]
[[http://www.uniprot.org/uniprot/RPOZ_ECO24 RPOZ_ECO24]] Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. [[http://www.uniprot.org/uniprot/RPOA_ECO24 RPOA_ECO24]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/RPOC_ECO24 RPOC_ECO24]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/RPOB_ECO24 RPOB_ECO24]] DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. [[http://www.uniprot.org/uniprot/RPOD_ECOLI RPOD_ECOLI]] Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This is the primary sigma factor of this bacterium.
[[Category: Murakami, K.S]]
__TOC__
[[Category: Fleming, P.R]]
</StructureSection>
[[Category: DNA-directed RNA polymerase]]
[[Category: Buurman, E T]]
[[Category: Eyermann, C J]]
[[Category: Ferguson, A D]]
[[Category: Fleming, P R]]
[[Category: Foulk, M A]]
[[Category: Masse, C E]]
[[Category: McKinney, D C]]
[[Category: Molodtsov, V]]
[[Category: Molodtsov, V]]
[[Category: Foulk, M.A]]
[[Category: Murakami, K S]]
[[Category: Ferguson, A.D]]
[[Category: Squaramide]]
[[Category: Masse, C.E]]
[[Category: Switch region]]
[[Category: Transcription-transcription inhibitor complex]]
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