5ajn: Difference between revisions
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''' | ==Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-Cys13== | ||
<StructureSection load='5ajn' size='340' side='right' caption='[[5ajn]], [[Resolution|resolution]] 1.67Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5ajn]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AJN OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AJN FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=A2G:N-ACETYL-2-DEOXY-2-AMINO-GALACTOSE'>A2G</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ajo|5ajo]], [[5ajp|5ajp]]</td></tr> | |||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Polypeptide_N-acetylgalactosaminyltransferase Polypeptide N-acetylgalactosaminyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.4.1.41 2.4.1.41] </span></td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ajn FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ajn OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ajn RCSB], [http://www.ebi.ac.uk/pdbsum/5ajn PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/GALT2_HUMAN GALT2_HUMAN]] Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region.<ref>PMID:9295285</ref> <ref>PMID:12438318</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Polypeptide N-acetylgalactosaminyltransferase]] | |||
[[Category: Bernado, P]] | |||
[[Category: Bernardes, G J.L]] | |||
[[Category: Bruscolini, P]] | [[Category: Bruscolini, P]] | ||
[[Category: Clausen, H]] | [[Category: Clausen, H]] | ||
[[Category: Companon, I]] | |||
[[Category: Corzana, F]] | |||
[[Category: Hurtado-Guerrero, R]] | |||
[[Category: Iglesias-Fernandez, J]] | |||
[[Category: Kong, Y]] | [[Category: Kong, Y]] | ||
[[Category: Lira-Navarrete, E]] | [[Category: Lira-Navarrete, E]] | ||
[[Category: Lostao, A]] | [[Category: Lostao, A]] | ||
[[Category: | [[Category: Pallares, M C]] | ||
[[Category: | [[Category: Peregrina, J M]] | ||
[[Category: | [[Category: Rovira, C]] | ||
[[Category: | [[Category: DelasRivas, M]] | ||
[[Category: Active form]] | |||
[[Category: Afm]] | |||
[[Category: Coarse-grained model]] | |||
[[Category: Compact form]] | |||
[[Category: Extended form]] | |||
[[Category: Glycopeptide]] | |||
[[Category: Inactive form]] | |||
[[Category: Lectin domain]] | |||
[[Category: Sax]] | |||
[[Category: Transferase]] | |||
Revision as of 12:02, 11 March 2015
Crystal structure of the inactive form of GalNAc-T2 in complex with the glycopeptide MUC5AC-Cys13
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Proteopedia Page Contributors and Editors (what is this?)
Categories:
- Polypeptide N-acetylgalactosaminyltransferase
- Bernado, P
- Bernardes, G J.L
- Bruscolini, P
- Clausen, H
- Companon, I
- Corzana, F
- Hurtado-Guerrero, R
- Iglesias-Fernandez, J
- Kong, Y
- Lira-Navarrete, E
- Lostao, A
- Pallares, M C
- Peregrina, J M
- Rovira, C
- DelasRivas, M
- Active form
- Afm
- Coarse-grained model
- Compact form
- Extended form
- Glycopeptide
- Inactive form
- Lectin domain
- Sax
- Transferase
