Sandbox Reserved 995: Difference between revisions
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== HEAT Repeat Motif == | == HEAT Repeat Motif == | ||
PP2A belongs in the HEAT Repeat Motif or Huntington-elongation-A subunit-TOR. The main backbone of PP2A are 15 repeating units or <scene name='69/691537/Heat/1'>HEAT units</scene>, each composed of a conserved 39-residue sequence.The HEAT Motif has a signature sequence of conserved residues asparagine at position 19 and arginine at position 25. Each HEAT unit consists of a pair of antiparallel alpha-helices. These antiparallel helices assemble in a L-shaped fashion resulting in an overall shape of a double layer of alpha helices. These HEAT units are responsible for a majority of the overall protein packing and structure by interactions of the ridges of each HEAT unit. | PP2A belongs in the HEAT Repeat Motif or Huntington-elongation-A subunit-TOR. The main backbone of PP2A are 15 repeating units or <scene name='69/691537/Heat/1'>HEAT units</scene>, each composed of a conserved 39-residue sequence.The HEAT Motif has a signature sequence of conserved residues asparagine at position 19 and arginine at position 25. Each HEAT unit consists of a pair of antiparallel alpha-helices. These antiparallel helices assemble in a L-shaped fashion resulting in an overall shape of a double layer of alpha helices. These HEAT units are responsible for a majority of the overall protein packing and structure by interactions of the ridges of each HEAT unit. <ref>PMID: 9989501</ref> | ||
== Huntington's Disease == | == Huntington's Disease == | ||
