Sandbox Reserved 995: Difference between revisions

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== Structure and Function ==

The <scene name='69/691537/Unita/1'>Aα subunit</scene> (or scaffolding subunit) along with the catalytic subunit makes up the core enzyme. Aα is composed of fifteen [[HEAT repeats]] that form a double layer of antiparallel alpha helices. The arrangement of the alpha helices causes the subunit to adopt a half circle shape. When in this conformation the Aα subunit is able to interact with the catalytic subunit via four-conserved HEAT repeats <ref> Xing, Yongna, Yanhui Xu, Yu Chen, Philip D. Jeffrey, Yang Chao, Zheng Lin, Zhu Li, Stefan Strack, Jeffry B. Stock, and Yigong Shi. "Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins." Cell (2006): 341-53.</ref>, causing a conformational activation of the catalytic subunit and creation of the core enzyme

The <scene name='69/691537/Unita/1'>Aα subunit</scene> (or scaffolding subunit) along with the catalytic subunit makes up the core enzyme. Aα is composed of fifteen HEAT repeats that form a double layer of antiparallel alpha helices. The arrangement of the alpha helices causes the subunit to adopt a half circle shape. When in this conformation the Aα subunit is able to interact with the catalytic subunit via four-conserved HEAT repeats <ref> Xing, Yongna, Yanhui Xu, Yu Chen, Philip D. Jeffrey, Yang Chao, Zheng Lin, Zhu Li, Stefan Strack, Jeffry B. Stock, and Yigong Shi. "Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins." Cell (2006): 341-53.</ref>, causing a conformational activation of the catalytic subunit and creation of the core enzyme

The <scene name='69/691537/Unitc/1'>Cα subunit</scene> (Catalytic subunit) associates with the A subunit to form a heterodimer protein. The catalytic subunit (in conjunction with the scaffolding and regulatory subunits) can have many functions and is a particularly important factor in cell growth regulation, signal transduction regulation, and cellular development as well as playing a key role in suppressing uncontrolled cell proliferation. It thought that the B subunit is largely responsible for the specific function of the A-C dimer.

Sandbox Reserved 995: Difference between revisions

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 == Structure and Function ==
-The <scene name='69/691537/Unita/1'>Aα subunit</scene> (or scaffolding subunit) along with the catalytic subunit makes up the core enzyme. Aα is composed of fifteen [[HEAT repeats]] that form a double layer of antiparallel alpha helices. The arrangement of the alpha helices causes the subunit to adopt a half circle shape. When in this conformation the Aα subunit is able to interact with the catalytic subunit via four-conserved HEAT repeats <ref> Xing, Yongna, Yanhui Xu, Yu Chen, Philip D. Jeffrey, Yang Chao, Zheng Lin, Zhu Li, Stefan Strack, Jeffry B. Stock, and Yigong Shi. "Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins." Cell (2006): 341-53.</ref>, causing a conformational activation of the catalytic subunit and creation of the core enzyme
+The <scene name='69/691537/Unita/1'>Aα subunit</scene> (or scaffolding subunit) along with the catalytic subunit makes up the core enzyme. Aα is composed of fifteen HEAT repeats that form a double layer of antiparallel alpha helices. The arrangement of the alpha helices causes the subunit to adopt a half circle shape. When in this conformation the Aα subunit is able to interact with the catalytic subunit via four-conserved HEAT repeats <ref> Xing, Yongna, Yanhui Xu, Yu Chen, Philip D. Jeffrey, Yang Chao, Zheng Lin, Zhu Li, Stefan Strack, Jeffry B. Stock, and Yigong Shi. "Structure of Protein Phosphatase 2A Core Enzyme Bound to Tumor-Inducing Toxins." Cell (2006): 341-53.</ref>, causing a conformational activation of the catalytic subunit and creation of the core enzyme
 The <scene name='69/691537/Unitc/1'>Cα subunit</scene> (Catalytic subunit) associates with the A subunit to form a heterodimer protein. The catalytic subunit (in conjunction with the scaffolding and regulatory subunits) can have many functions and is a particularly important factor in cell growth regulation, signal transduction regulation, and cellular development as well as playing a key role in suppressing uncontrolled cell proliferation. It thought that the B subunit is largely responsible for the specific function of the A-C dimer.