4yik: Difference between revisions
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''' | ==Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU== | ||
<StructureSection load='4yik' size='340' side='right' caption='[[4yik]], [[Resolution|resolution]] 1.48Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4yik]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YIK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YIK FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2O2:1-{2-DEOXY-3,5-O-[PHENYL(PHOSPHONO)METHYLIDENE]-BETA-D-THREO-PENTOFURANOSYL}-5-[(E)-2-PHOSPHONOETHENYL]PYRIMIDINE-2,4(1H,3H)-DIONE'>2O2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4yih|4yih]]</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yik FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yik OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yik RCSB], [http://www.ebi.ac.uk/pdbsum/4yik PDBsum]</span></td></tr> | |||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/NT5M_HUMAN NT5M_HUMAN]] Dephosphorylates specifically the 5' and 2'(3')-phosphates of uracil and thymine deoxyribonucleotides, and so protects mitochondrial DNA replication from excess dTTP. Has only marginal activity towards dIMP and dGMP. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Brynda, J]] | [[Category: Brynda, J]] | ||
[[Category: Pachl, P]] | [[Category: Pachl, P]] | ||
[[Category: Rezacova, P]] | [[Category: Rezacova, P]] | ||
[[Category: 5'-nucleotidase]] | |||
[[Category: Dephosphorylation]] | |||
[[Category: Had-like]] | |||
[[Category: Hydrolase-hydrolase inhibitor complex]] | |||
[[Category: Mitochondria]] | |||
[[Category: Phosphorylation]] | |||
Revision as of 11:21, 9 September 2015
Crystal structure of human cytosolic 5'(3')-deoxyribonucleotidase in complex with the inhibitor PB-PVU
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