2qt1: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
|PDB= 2qt1 |SIZE=350|CAPTION= <scene name='initialview01'>2qt1</scene>, resolution 1.320Å | |PDB= 2qt1 |SIZE=350|CAPTION= <scene name='initialview01'>2qt1</scene>, resolution 1.320Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand= | |LIGAND= <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NNR:NICOTINAMIDE+RIBOSIDE'>NNR</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=UNX:UNKNOWN+ATOM+OR+ION'>UNX</scene> | ||
|ACTIVITY= | |ACTIVITY= | ||
|GENE= NRK1, C9orf95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | |GENE= NRK1, C9orf95 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 Homo sapiens]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2qsy|2QSY]], [[2qsz|2QSZ]], [[2qt0|2QT0]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2qt1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2qt1 OCA], [http://www.ebi.ac.uk/pdbsum/2qt1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2qt1 RCSB]</span> | |||
}} | }} | ||
| Line 34: | Line 37: | ||
[[Category: Tempel, W.]] | [[Category: Tempel, W.]] | ||
[[Category: Weigelt, J.]] | [[Category: Weigelt, J.]] | ||
[[Category: adp]] | [[Category: adp]] | ||
[[Category: alternative splicing]] | [[Category: alternative splicing]] | ||
| Line 54: | Line 54: | ||
[[Category: transferase]] | [[Category: transferase]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:53:00 2008'' | ||
Revision as of 01:53, 31 March 2008
| |||||||||||||
| 2qt1, resolution 1.320Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | MSE, NNR, PO4, UNX | ||||||||||||
| Gene: | NRK1, C9orf95 (Homo sapiens) | ||||||||||||
| Related: | 2QSY, 2QSZ, 2QT0
| ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Human nicotinamide riboside kinase 1 in complex with nicotinamide riboside
Overview
The eukaryotic nicotinamide riboside kinase (Nrk) pathway, which is induced in response to nerve damage and promotes replicative life span in yeast, converts nicotinamide riboside to nicotinamide adenine dinucleotide (NAD+) by phosphorylation and adenylylation. Crystal structures of human Nrk1 bound to nucleoside and nucleotide substrates and products revealed an enzyme structurally similar to Rossmann fold metabolite kinases and allowed the identification of active site residues, which were shown to be essential for human Nrk1 and Nrk2 activity in vivo. Although the structures account for the 500-fold discrimination between nicotinamide riboside and pyrimidine nucleosides, no enzyme feature was identified to recognize the distinctive carboxamide group of nicotinamide riboside. Indeed, nicotinic acid riboside is a specific substrate of human Nrk enzymes and is utilized in yeast in a novel biosynthetic pathway that depends on Nrk and NAD+ synthetase. Additionally, nicotinic acid riboside is utilized in vivo by Urh1, Pnp1, and Preiss-Handler salvage. Thus, crystal structures of Nrk1 led to the identification of new pathways to NAD+.
About this Structure
2QT1 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.
Reference
Nicotinamide riboside kinase structures reveal new pathways to NAD+., Tempel W, Rabeh WM, Bogan KL, Belenky P, Wojcik M, Seidle HF, Nedyalkova L, Yang T, Sauve AA, Park HW, Brenner C, PLoS Biol. 2007 Oct 2;5(10):e263. PMID:17914902
Page seeded by OCA on Mon Mar 31 04:53:00 2008
Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Homo sapiens
- Single protein
- Arrowsmith, C H.
- Bochkarev, A.
- Brenner, C.
- Edwards, A M.
- Landry, R.
- Nedyalkova, L.
- Park, H.
- Rabeh, W M.
- SGC, Structural Genomics Consortium.
- Sundstrom, M.
- Tempel, W.
- Weigelt, J.
- Adp
- Alternative splicing
- Atp-binding
- Nad biosynthesis
- Nad+
- Nicotinamide riboside
- Nicotinamide riboside kinase activity
- Nicotinic acid riboside kinase activity
- Non-protein kinase
- Nrk1
- Nucleotide-binding
- Pyridine nucleotide biosynthesis
- Sgc
- Structural genomic
- Structural genomics consortium
- Transferase
