Chaperonin: Difference between revisions

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{{STRUCTURE_1pcq|  PDB=1pcq  | SIZE=400| SCENE=Chaperonin/Groel_groes_comnplex/1 |right|CAPTION=GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions, [[1pcq]] }}
{{STRUCTURE_1pcq|  PDB=1pcq  | SIZE=400| SCENE=Chaperonin/Groel_groes_comnplex/1 |right|CAPTION=GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions, [[1pcq]] }}


 
<StructureSection load='1pcq' size='350' side='right' caption='GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry [[1pcq]])' scene=''>
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 


'''Chaperonins''' (CPN) are oligomeric proteins that mediate the folding of polypeptide chains.  Group I CPN are found in bacteria, chloroplasts and mitochondria.  For an introductory overview, see [http://en.wikipedia.org/wiki/Chaperonins Chaperonins in Wikipedia].
'''Chaperonins''' (CPN) are oligomeric proteins that mediate the folding of polypeptide chains.  Group I CPN are found in bacteria, chloroplasts and mitochondria.  For an introductory overview, see [http://en.wikipedia.org/wiki/Chaperonins Chaperonins in Wikipedia].
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The most characterized CPN are in the GroEL/GroES complex from ''Escherichia coli'' and CPN60/CPN10 from ''Thermus thermophilus''.  The larger subunit (GroEL, CPN60) contains 3 domains.  The apical domain is the one which binds the substrate.  Group II CPNs are found in eukaryotic cytosol and archaea.  Thermosome is a CPN complex found in archaea.  CCT is a CPN complex found in eukarya.
The most characterized CPN are in the GroEL/GroES complex from ''Escherichia coli'' and CPN60/CPN10 from ''Thermus thermophilus''.  The larger subunit (GroEL, CPN60) contains 3 domains.  The apical domain is the one which binds the substrate.  Group II CPNs are found in eukaryotic cytosol and archaea.  Thermosome is a CPN complex found in archaea.  CCT is a CPN complex found in eukarya.
See also [[Chaperones]].
See also [[Chaperones]].
 
</StructureSection>
== 3D Structures of Chaperonin ==
== 3D Structures of Chaperonin ==


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**[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br />
**[[3j1f]] - AtTherm β subunit + ATP – Cryo EM <br />
**[[3aq1]] – Therm – ''Methanococcoides burtonii''<br />
**[[3aq1]] – Therm – ''Methanococcoides burtonii''<br />
**[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – Thermococcus KS-1<br />
**[[1q2v]], [[1q3r]] – TkTherm α subunit (mutant) – ''Thermococcus KS-1''<br />
**[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br />
**[[1q3q]] - TkTherm α subunit (mutant) + AMP-PNP<br />
**[[1q3s]] - TkTherm α subunit (mutant) + ADP<br />
**[[1q3s]] - TkTherm α subunit (mutant) + ADP<br />
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**[[1lep]] – CPN-10 – ''Mycobacterium leprae''
**[[1lep]] – CPN-10 – ''Mycobacterium leprae''
}}
}}
 
== References ==
<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 11:28, 6 December 2015

Crystal Structure of Chaperonin, 1pcq

Template:STRUCTURE 1pcq

GroEL/GroES complex with ADP, AlF3, Mg+2 and K+ ions (PDB entry 1pcq)

Drag the structure with the mouse to rotate

3D Structures of Chaperonin

Updated on 06-December-2015

See Heat Shock Proteins

  • Thermosome
    • 1a6d - TaTherm α+β subunits – Thermoplasma acidophilum
    • 1a6e - TaTherm α+β subunits + ADP
    • 1ass, 1asx - TaTherm α apical domain
    • 1e0r – TaTherm β apical domain
    • 3ko1 – AtTherm α subunit– Acidianus tengchongensis
    • 3j1b, 3j1c, 3j1e - AtTherm α subunit – Cryo EM
    • 3j1f - AtTherm β subunit + ATP – Cryo EM
    • 3aq1 – Therm – Methanococcoides burtonii
    • 1q2v, 1q3r – TkTherm α subunit (mutant) – Thermococcus KS-1
    • 1q3q - TkTherm α subunit (mutant) + AMP-PNP
    • 1q3s - TkTherm α subunit (mutant) + ADP
    • 1lep – CPN-10 – Mycobacterium leprae

References

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