4q1p: Difference between revisions
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''' | ==Galectin-1 in Complex with Ligand NB169== | ||
<StructureSection load='4q1p' size='340' side='right' caption='[[4q1p]], [[Resolution|resolution]] 1.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[4q1p]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4Q1P OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4Q1P FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2XT:PROPYL+2-(ACETYLAMINO)-4-O-{3-O-[(1-BENZYL-1H-1,2,3-TRIAZOL-4-YL)METHYL]-BETA-D-GALACTOPYRANOSYL}-2-DEOXY-BETA-D-GLUCOPYRANOSIDE'>2XT</scene>, <scene name='pdbligand=BME:BETA-MERCAPTOETHANOL'>BME</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CME:S,S-(2-HYDROXYETHYL)THIOCYSTEINE'>CME</scene></td></tr> | |||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4q1r|4q1r]], [[4q26|4q26]], [[4q27|4q27]], [[4q2f|4q2f]]</td></tr> | |||
[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4q1p FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4q1p OCA], [http://pdbe.org/4q1p PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4q1p RCSB], [http://www.ebi.ac.uk/pdbsum/4q1p PDBsum]</span></td></tr> | ||
</table> | |||
== Function == | |||
[[http://www.uniprot.org/uniprot/LEG1_HUMAN LEG1_HUMAN]] May regulate apoptosis, cell proliferation and cell differentiation. Binds beta-galactoside and a wide array of complex carbohydrates. Inhibits CD45 protein phosphatase activity and therefore the dephosphorylation of Lyn kinase.<ref>PMID:14617626</ref> <ref>PMID:18796645</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Bertleff-Zieschang, N]] | [[Category: Bertleff-Zieschang, N]] | ||
[[Category: Grimm, C]] | [[Category: Grimm, C]] | ||
[[Category: Rational drug design]] | |||
[[Category: Sugar binding protein]] | |||
Revision as of 13:48, 7 October 2015
Galectin-1 in Complex with Ligand NB169
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