3x43: Difference between revisions
From Proteopedia
Jump to navigationJump to search
m Protected "3x43" [edit=sysop:move=sysop] |
No edit summary |
||
| Line 1: | Line 1: | ||
''' | ==Crystal structure of O-ureido-L-serine synthase== | ||
<StructureSection load='3x43' size='340' side='right' caption='[[3x43]], [[Resolution|resolution]] 2.25Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[3x43]] is a 8 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3X43 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3X43 FirstGlance]. <br> | |||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=PLP:PYRIDOXAL-5-PHOSPHATE'>PLP</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3x43 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3x43 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3x43 RCSB], [http://www.ebi.ac.uk/pdbsum/3x43 PDBsum]</span></td></tr> | |||
</table> | |||
[[Category: | == Function == | ||
[[http://www.uniprot.org/uniprot/DCSD_STRLA DCSD_STRLA]] Involved in the biosynthesis of the antibiotic D-cycloserine (DCS), a cyclic structural analog of D-alanine, used as an antitubercular agent. Catalyzes the addition of hydroxyurea on O-acetyl-L-serine (OAS) to yield O-ureido-L-serine. It prefers sulfide as the second substrate, followed by hydroxyurea, L-homocysteine, and thiosulfate.<ref>PMID:20086163</ref> <ref>PMID:23529730</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Matoba, Y]] | |||
[[Category: Oda, K]] | [[Category: Oda, K]] | ||
[[Category: | [[Category: Sugiyama, M]] | ||
[[Category: Uda, N]] | [[Category: Uda, N]] | ||
[[Category: | [[Category: D-cycloserine]] | ||
[[Category: Synthase]] | |||
[[Category: Transferase]] | |||
[[Category: Type ii plp enzyme]] | |||
Revision as of 14:45, 29 July 2015
Crystal structure of O-ureido-L-serine synthase
| ||||||||||||
