Sandbox Reserved 1058: Difference between revisions
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[[Image:Normal_Crystal_Structure.png|250 px|center|thumb|'''Figure 1. Structure of Isocitrate Lyase.''' Quaternary structure is comprised of four subunits forming an alpha/beta barrel.]] | [[Image:Normal_Crystal_Structure.png|250 px|center|thumb|'''Figure 1. Structure of Isocitrate Lyase.''' Quaternary structure is comprised of four subunits forming an alpha/beta barrel.]] | ||
Isocitrate lyase is a tetramer with 222 symmetry. Each subunit is composed of 14 alpha helices and 14 beta sheets. A unique structural feature of this enzyme is a phenomenon called "helix swapping" '''GREEN BUTTON'''. | Isocitrate lyase is a tetramer with 222 symmetry. Each subunit is composed of 14 alpha helices and 14 beta sheets. A unique structural feature of this enzyme is a phenomenon called "helix swapping" '''GREEN BUTTON'''. | ||
Helix swapping is observed between two monomers to form stable dimers. The 11th and 12th helices of each monomer exchange three dimensional placement with the respective helices of the opposite monomer. Due to the 222 symmetry observed, only two dimers form than combine to form the observed tetramer. | |||
== Function == | == Function == | ||
