Sandbox Reserved 995: Difference between revisions
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=Protein Phosphatase 2A= | =Protein Phosphatase 2A= | ||
Protein Phosphatase 2A is a catalytic protein that is involved in many biological pathways. In this article, we will discuss it's function in Huntington's Disease. PP2A is a three subunit holoenzyme that interacts with CAG (cytosine-adenine-guanine) levels in the | Protein Phosphatase 2A is a catalytic protein that is involved in many biological pathways. In this article, we will discuss it's function in Huntington's Disease. PP2A is a three subunit holoenzyme that interacts with CAG (cytosine-adenine-guanine) levels in the huntingtin gene [http://en.wikipedia.org/wiki/Huntingtin/ huntingtin gene] which codes for the amino acid glutamine. PP2A upregulates this protein sequence by an unclear mechanism. An upward excess of 35 or more CAG repeating units is the cause of the neurodegenerative disorder referred to as Huntington. <ref>PMID: 19748341</ref> | ||
<Structure load='2NPP' size='400' frame='true' align='right' caption='Protein Phosphatase 2A' scene='69/691537/Starter/1' /> | <Structure load='2NPP' size='400' frame='true' align='right' caption='Protein Phosphatase 2A' scene='69/691537/Starter/1' /> | ||
