Practical Guide to Homology Modeling: Difference between revisions
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== Are parts (or all) of the query protein intrinsically disordered? == | == Are parts (or all) of the query protein intrinsically disordered? == | ||
Attempts to determine structure for intrinsically disordered protein will be futile. Therefore, before considering homology modeling or crystallization experiments, it is important to predict whether portions of the query protein are likely to be intrinsically disordered. | Attempts to determine structure for [[Intrinsically Disordered Protein|intrinsically disordered]] protein will be futile. Therefore, before considering homology modeling or crystallization experiments, it is important to predict whether portions of the query protein are likely to be intrinsically disordered. | ||
Although fold is required for the function of most proteins, some proteins are [[Intrinsically Disordered Protein|intrinsically disordered]] (natively unstructured) and do not fold, at least by themselves. Often, intrinsically disordered protein transitions to an ordered state when it binds to a folded partner protein. However some proteins remain disordered while performing their functions. | Although fold is required for the function of most proteins, some proteins are [[Intrinsically Disordered Protein|intrinsically disordered]] (natively unstructured) and do not fold, at least by themselves. Often, intrinsically disordered protein transitions to an ordered state when it binds to a folded partner protein. However some proteins remain disordered while performing their functions. | ||
