2rcu: Difference between revisions
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|PDB= 2rcu |SIZE=350|CAPTION= <scene name='initialview01'>2rcu</scene>, resolution 1.78Å | |PDB= 2rcu |SIZE=350|CAPTION= <scene name='initialview01'>2rcu</scene>, resolution 1.78Å | ||
|SITE= | |SITE= | ||
|LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene> | |LIGAND= <scene name='pdbligand=BOG:B-OCTYLGLUCOSIDE'>BOG</scene>, <scene name='pdbligand=BUJ:(3R)-3-(HEXADECANOYLAMINO)-4-(TRIMETHYLAMMONIO)BUTANOATE'>BUJ</scene> | ||
|ACTIVITY= [http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] | |ACTIVITY= <span class='plainlinks'>[http://en.wikipedia.org/wiki/Carnitine_O-palmitoyltransferase Carnitine O-palmitoyltransferase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.3.1.21 2.3.1.21] </span> | ||
|GENE= Cpt2, Cpt-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | |GENE= Cpt2, Cpt-2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10116 Rattus norvegicus]) | ||
|DOMAIN= | |||
|RELATEDENTRY=[[2deb|2DEB]], [[2fw3|2FW3]], [[2fyo|2FYO]], [[2h4t|2H4T]] | |||
|RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2rcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2rcu OCA], [http://www.ebi.ac.uk/pdbsum/2rcu PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=2rcu RCSB]</span> | |||
}} | }} | ||
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[[Category: Rufer, A C.]] | [[Category: Rufer, A C.]] | ||
[[Category: Thoma, R.]] | [[Category: Thoma, R.]] | ||
[[Category: acetylation]] | [[Category: acetylation]] | ||
[[Category: acyltransferase]] | [[Category: acyltransferase]] | ||
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[[Category: transport]] | [[Category: transport]] | ||
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Mar 31 04:58:56 2008'' | ||
Revision as of 01:58, 31 March 2008
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| 2rcu, resolution 1.78Å | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ligands: | BOG, BUJ | ||||||||||||
| Gene: | Cpt2, Cpt-2 (Rattus norvegicus) | ||||||||||||
| Activity: | Carnitine O-palmitoyltransferase, with EC number 2.3.1.21 | ||||||||||||
| Related: | 2DEB, 2FW3, 2FYO, 2H4T
| ||||||||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||||||||
Crystal structure of rat carnitine palmitoyltransferase 2 in complex with r-3-(hexadecanoylamino)-4-(trimethylazaniumyl)butanoate
Overview
The mitochondrial membrane-associated carnitine palmitoyltransferase system is a validated target for the treatment of type 2 diabetes mellitus. To further facilitate structure-based drug discovery, we determined the crystal structure of rat CPT-2 (rCPT-2) in complex with the substrate analogue palmitoyl-aminocarnitine at 1.8A resolution. Biochemical analyses revealed a strong effect of this compound on rCPT-2 activity and stability. Using a computational approach we examined the membrane association of rCPT-2. The protein interacts with the membrane as a functional monomer and the calculations confirm the presence of a membrane association domain that consists of layers of hydrophobic and positively charged residues.
About this Structure
2RCU is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Carnitine palmitoyltransferase 2: analysis of membrane association and complex structure with a substrate analog., Rufer AC, Lomize A, Benz J, Chomienne O, Thoma R, Hennig M, FEBS Lett. 2007 Jul 10;581(17):3247-52. Epub 2007 Jun 8. PMID:17585909
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Proteopedia Page Contributors and Editors (what is this?)
- Pages with broken file links
- Carnitine O-palmitoyltransferase
- Rattus norvegicus
- Single protein
- Benz, J.
- Chomienne, O.
- Hennig, M.
- Rufer, A C.
- Thoma, R.
- Acetylation
- Acyltransferase
- Fatty acid metabolism
- Inner membrane
- Lipid metabolism
- Membrane
- Mitochondrial protein
- Mitochondrion
- Transferase
- Transferase 04-mai-06 r
- Transit peptide
- Transport
