Sandbox Reserved 1066: Difference between revisions
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''Mycobacterium tuberculosis'' very-long-chain fatty acyl-CoA synthetase, also known as FadD13, is unique within its class in regards to its ability to house lipid substrates longer than itself. Most FadD class proteins exist as integral membrane proteins involved in lipid transport into the cell. FadD13 is unique structurally in that it exists as a peripheral protein on the inside of the cell membrane. This feature is key in the mechanistic basis for FadD13's transport of fatty acids of length C24-C26. | ''Mycobacterium tuberculosis'' very-long-chain fatty acyl-CoA synthetase, also known as FadD13, is unique within its class in regards to its ability to house lipid substrates longer than itself. Most FadD class proteins exist as integral membrane proteins involved in lipid transport into the cell. FadD13 is unique structurally in that it exists as a peripheral protein on the inside of the cell membrane. This feature is key in the mechanistic basis for FadD13's transport of fatty acids of length C24-C26. | ||
FadD13 may be important in the virulence of [[tuberculosis]] and has emerged as possible target for therapeutic agents. | |||
= Mechanism = | = Mechanism = | ||
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== Hydrophobic Tunnel == | == Hydrophobic Tunnel == | ||
The hydrophobic tunnel of FadD13 is essential to the transport of very long fatty acids from the membrane into the cell. | The hydrophobic tunnel of FadD13 is essential to the transport and accommodation of very long fatty acids from the membrane into the cell. This region is situated through the middle of FadD13 from the arginine rich lid loop to the active site. | ||
== Active Site == | == Active Site == | ||
The active site on FadD13 is composed of two conserved regions, one of which serves as the binding site for ATP and the other for CoA. | The active site on FadD13 is composed of two conserved regions, one of which serves as the binding site for ATP and the other for CoA. The | ||
= Disease = | = Disease = | ||
''Mycobacterium tuberculosis'' is the causative agent involved in the disease '''tuberculosis'''. | ''Mycobacterium tuberculosis'' is the causative agent involved in the disease '''tuberculosis'''. | ||
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This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | This is a sample scene created with SAT to <scene name="/12/3456/Sample/1">color</scene> by Group, and another to make <scene name="/12/3456/Sample/2">a transparent representation</scene> of the protein. You can make your own scenes on SAT starting from scratch or loading and editing one of these sample scenes. | ||
</StructureSection> | </StructureSection> | ||
== References == | |||
==References== | |||
<references/> | <references/> | ||
==Similar Proteopedia Pages== | |||
[http://www.proteopedia.org/wiki/index.php/Thioesterase Thioesterase] Do we have anything like this? | |||
==External Resources== | |||
[https://en.wikipedia.org/wiki/Tuberculosis Tuberculosis] Wikipedia page | |||
[https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis''] Wikipedia page | |||
[https://en.wikipedia.org/wiki/Acyl-CoA Acyl-CoA] Wikipedia page | |||
[https://en.wikipedia.org/wiki/Mycolic_acid Mycolic Acid] Wikipedia page | |||
