Exportin

spinqualitylabelsall models Structure of yeast exportin-5 (dark green and dark red) complex with GTPaseRan (pale green and pink), Mg+2 (green) and RNA (PDB code 3icq). Show:Asymmetric Unit Biological Assembly Drag the structure with the mouse to rotate   Export Animated Image   Print3D Function Exportins (XPO) or chromosomal maintenance protein mediate the nuclear export of cellular proteins with a leucine-rich export signal (NES) and RNA. XPO is regulated by GTPaseRan. RanGTP bind to XPO forming a ternary complex with the exported protein. The complex diffuses through the nuclear core complex to the cytoplasm and then dissociates. XPO-t exports tRNA from the nucleus.

3D structures of exportin

Updated on 20-January-2016

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• XPO-1
  • 4bsm, 4bsn – hXPO – human
    
  • 1w9c – hXPO C terminal 6 heat repeats
    
  • 3vyc – yXPO (mutant) - yeast
    
  • 4fgv – XPO – Chaetomium thermophilum
    
• XPO-1 complexes
  • 3gb8 – hXPO + RNA U transporter 1
    
  • 3gjx – hXPO + RNA U transporter 1 + GTPaseRan
    
  • 3m1i, 4gpt, 4gmx, 4hat, 4hb2 – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein
    
  • 3wyf – yXPO + GTP-binding nuclear protein + Ran-specific GTPase-activating protein
    
  • 3wyg – yXPO + GTP-binding nuclear protein + PKI-alpha
    
  • 4hau, 4hav, 4haw, 4hax, 4hay, 4haz, 4hb0, 4hb3, 4hb4 – yXPO (mutant) + GTP-binding nuclear protein + Ran-specific GTPase-activating protein + antibiotic
    
  • 3nby, 3nbz, 3nc0 – mXPO + RNA U transporter 1 + GTPaseRan - mouse
    
  • 3nc1 – mXPO + GTPaseRan
    
  • 2l1l – hXPO residues 504-630 + cAMP-dependent protein kinase inhibitor α - NMR
    
• XPO-t
  • 3ibv – fyXPO – fission yeast
    
  • 3icq – fyXPO + GTP-binding nuclear protein + RNA
    
• XPO-5
  • 3a6p – hXPO + peptide + pre-microRNA
    

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Michal Harel, Alexander Berchansky