4ynr: Difference between revisions

Line 1:

~~'''Unreleased structure'''~~

~~The entry~~ 4ynr is ~~ON HOLD until Paper Publication~~

==DosS GAFA Domain Reduced CO Bound Crystal Structure==

~~Authors~~: ~~Madrona~~, Y.

== Structural highlights ==

<table><tr><td colspan='2'>[[4ynr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNR OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YNR FirstGlance].

~~Description~~: DosS ~~GAFA Domain Reduced~~ CO ~~Bound Crystal Structure~~

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='related'><td class="sblockLbl">[[Related_structure|Related:]]</td><td class="sblockDat">[[2w3d|2w3d]], [[2w3f|2w3f]]</td></tr>

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </td></tr>

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ynr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ynr OCA], [http://pdbe.org/4ynr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ynr RCSB], [http://www.ebi.ac.uk/pdbsum/4ynr PDBsum]</td></tr>

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DEVS_MYCTO DEVS_MYCTO]] Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to DevR (DosR) (By similarity).

__TOC__

</StructureSection>

[[Category: Histidine kinase]]

[[Category: Madrona, Y]]

[[Category: Doss]]

[[Category: Gas sensor]]

[[Category: Heme]]

[[Category: Oxidoreductase]]

[[Category: Tuberculosis]]

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@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 4ynr is ON HOLD  until Paper Publication
+==DosS GAFA Domain Reduced CO Bound Crystal Structure==
+<StructureSection load='4ynr' size='340' side='right' caption='[[4ynr]], [[Resolution|resolution]] 1.92&Aring;' scene=''>
-Authors: Madrona, Y.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4ynr]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YNR OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YNR FirstGlance]. <br>
-Description: DosS GAFA Domain Reduced CO Bound Crystal Structure
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CMO:CARBON+MONOXIDE'>CMO</scene>, <scene name='pdbligand=HEM:PROTOPORPHYRIN+IX+CONTAINING+FE'>HEM</scene></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2w3d|2w3d]], [[2w3f|2w3f]]</td></tr>
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Histidine_kinase Histidine kinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.13.3 2.7.13.3] </span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ynr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ynr OCA], [http://pdbe.org/4ynr PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ynr RCSB], [http://www.ebi.ac.uk/pdbsum/4ynr PDBsum]</span></td></tr>
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DEVS_MYCTO DEVS_MYCTO]] Member of the two-component regulatory system DevR/DevS (DosR/DosS) involved in onset of the dormancy response. May act as a redox sensor (rather than a direct hypoxia sensor); the normal (aerobic growth) state is the Fe(3+) form, while the reduced (anaerobic growth) Fe(2+) form is probably active for phosphate transfer. It is probably reduced by flavin nucleotides such as FMN and FAD. May be the primary sensor for CO. Donates a phosphate group to DevR (DosR) (By similarity).
+__TOC__
+</StructureSection>
+[[Category: Histidine kinase]]
 [[Category: Madrona, Y]]
+[[Category: Doss]]
+[[Category: Gas sensor]]
+[[Category: Heme]]
+[[Category: Oxidoreductase]]
+[[Category: Tuberculosis]]