4yxm: Difference between revisions

Line 1:

'''~~Unreleased structure~~'''

==Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP==

~~The entry~~ 4yxm is ~~ON HOLD until Paper Publication~~

== Structural highlights ==

<table><tr><td colspan='2'>[[4yxm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXM OCA]. For a guided tour on the structure components use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXM FirstGlance].

~~Authors~~: ~~Mueller~~, M., ~~Deimling~~, T., ~~Hopfner~~, K.-P., ~~Witte, G~~.

</td></tr><tr id='ligand'><td class="sblockLbl">[[Ligand|Ligands:]]</td><td class="sblockDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>

~~Description~~:

<tr id='activity'><td class="sblockLbl">Activity:</td><td class="sblockDat">[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </td></tr>

[[Category: ~~Unreleased Structures~~]]

<tr id='resources'><td class="sblockLbl">Resources:</td><td class="sblockDat">[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yxm RCSB], [http://www.ebi.ac.uk/pdbsum/4yxm PDBsum]</td></tr>

[[Category: Hopfner, K.-P]]

</table>

== Function ==

[[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref> Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>

== References ==

__TOC__

</StructureSection>

[[Category: Diadenylate cyclase]]

[[Category: Deimling, T]]

[[Category: Hopfner, K P]]

[[Category: Mueller, M]]

[[Category: Witte, G]]

[[Category: ~~Deimling, T~~]]

[[Category: C-di-amp synthesis]]

[[Category: Dac domain]]

[[Category: Dna binding protein]]

[[Category: Inhibitor]]

[[Category: Pre-reaction state]]

[[Category: Transferase]]

Navigation menu

Page actions

Page actions

Personal tools

Navigation

Search

Tools

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
+==Structure of Thermotoga maritima DisA D75N mutant with reaction product c-di-AMP==
+<StructureSection load='4yxm' size='340' side='right' caption='[[4yxm]], [[Resolution|resolution]] 2.25&Aring;' scene=''>
-The entry 4yxm is ON HOLD  until Paper Publication
+== Structural highlights ==
+<table><tr><td colspan='2'>[[4yxm]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4YXM OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4YXM FirstGlance]. <br>
-Authors: Mueller, M., Deimling, T., Hopfner, K.-P., Witte, G.
+</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=2BA:(2R,3R,3AS,5R,7AR,9R,10R,10AS,12R,14AR)-2,9-BIS(6-AMINO-9H-PURIN-9-YL)OCTAHYDRO-2H,7H-DIFURO[3,2-D 3,2-J][1,3,7,9,2,8]TETRAOXADIPHOSPHACYCLODODECINE-3,5,10,12-TETROL+5,12-DIOXIDE'>2BA</scene>, <scene name='pdbligand=MPD:(4S)-2-METHYL-2,4-PENTANEDIOL'>MPD</scene></td></tr>
+<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3c1y|3c1y]], [[3c1z|3c1z]], [[3c21|3c21]], [[3c23|3c23]], [[4yvz|4yvz]], [[4yxj|4yxj]]</td></tr>
-Description:
+<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Diadenylate_cyclase Diadenylate cyclase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.7.85 2.7.7.85] </span></td></tr>
-[[Category: Unreleased Structures]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4yxm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4yxm OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4yxm RCSB], [http://www.ebi.ac.uk/pdbsum/4yxm PDBsum]</span></td></tr>
-[[Category: Hopfner, K.-P]]
+</table>
+== Function ==
+[[http://www.uniprot.org/uniprot/DISA_THEMA DISA_THEMA]] Participates in a DNA-damage check-point. DisA forms globular foci that rapidly scan along the chromosomes searching for lesions (By similarity).<ref>PMID:18439896</ref>   Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP likely acts as a signaling molecule that may couple DNA integrity with a cellular process. Does not convert GTP to c-di-GMP.<ref>PMID:18439896</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Diadenylate cyclase]]
+[[Category: Deimling, T]]
+[[Category: Hopfner, K P]]
 [[Category: Mueller, M]]
 [[Category: Witte, G]]
-[[Category: Deimling, T]]
+[[Category: C-di-amp synthesis]]
+[[Category: Dac domain]]
+[[Category: Dna binding protein]]
+[[Category: Inhibitor]]
+[[Category: Pre-reaction state]]
+[[Category: Transferase]]