Sandbox Reserved 992: Difference between revisions
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'''Class C β-lactamases''' are a subcategory of β-lactamase enzymes. These enzymes are produced by some bacteria and result in their resistance to a variety of β-lactam antibiotics. β-lactam antibiotics are classified based on their chemical structure which contains a four membered, amide containing ring known as the β-lactam ring. <scene name='69/691534/Class_c_beta-lactamase/1'>Class C β-lactamases</scene><ref>Powers, Rachel, Hollister C. Swanson, Magdalena A. Taracila, Nicholas W. Florek, Chiara Romagnoli, Emilia Caselli, Fabio Prati, Robert A. Bonomo, and Bradley J. Wallar. Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase of Acinetobacter baumannii. Biochemistry, 2014, 53 (48), 7670-7679.</ref> specifically target [http://en.m.wikipedia.org/wiki/Cephalosporin cephalosporin] antibiotics and deactivate their antimicrobial activity by hydrolyzing the [http://en.m.wikipedia.org/wiki/Β-lactam β-lactam ring]. | '''Class C β-lactamases''' are a subcategory of β-lactamase enzymes. These enzymes are produced by some bacteria and result in their resistance to a variety of β-lactam antibiotics. β-lactam antibiotics are classified based on their chemical structure which contains a four membered, amide containing ring known as the β-lactam ring. <scene name='69/691534/Class_c_beta-lactamase/1'>Class C β-lactamases</scene><ref>Powers, Rachel, Hollister C. Swanson, Magdalena A. Taracila, Nicholas W. Florek, Chiara Romagnoli, Emilia Caselli, Fabio Prati, Robert A. Bonomo, and Bradley J. Wallar. Biochemical and Structural Analysis of Inhibitors Targeting the ADC-7 Cephalosporinase of Acinetobacter baumannii. Biochemistry, 2014, 53 (48), 7670-7679.</ref> specifically target [http://en.m.wikipedia.org/wiki/Cephalosporin cephalosporin] antibiotics and deactivate their antimicrobial activity by hydrolyzing the [http://en.m.wikipedia.org/wiki/Β-lactam β-lactam ring]. | ||
<Structure load='1ke4' size='400' frame='true' color='white' align='right' caption='Class C Beta-lactamase' / | <Structure load='1ke4' size='400' frame='true' color='white' align='right' caption='Class C Beta-lactamase' scene='69/691534/Class_c_beta-lactamase/1'/> | ||
{| class="wikitable mw-collapsible" border="1" cellpadding="5" cellspacing="0" align="center" style="float: right; border: 1px solid #BBB; margin: .46em 0 0 .2em;" | {| class="wikitable mw-collapsible" border="1" cellpadding="5" cellspacing="0" align="center" style="float: right; border: 1px solid #BBB; margin: .46em 0 0 .2em;" | ||
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| [http://en.wikipedia.org/wiki/KEGG KEGG] || [http://www.genome.jp/dbget-bin/www_bget?ec:3.5.2.6 β-lactamases] | | [http://en.wikipedia.org/wiki/KEGG KEGG] || [http://www.genome.jp/dbget-bin/www_bget?ec:3.5.2.6 β-lactamases] | ||
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! class="mw-collapsible mw-collapsed wikitable" style="background: #efefef;" colspan="2" |Search | |||
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|[http://en.wikipedia.org/wiki/National_Center_for_Biotechnology_Information NCBI] || [http://www.ncbi.nlm.nih.gov/protein?term=3.5.2.6%5BEC/RN%20Number%5D%20AND%20%28cephalosporinase%5BAll%20Fields%5D%20OR%20%22class%20c%20beta%20lactamase%22%5BAll%20Fields%5D%29&cmd=DetailsSearch proteins] | |[http://en.wikipedia.org/wiki/National_Center_for_Biotechnology_Information NCBI] || [http://www.ncbi.nlm.nih.gov/protein?term=3.5.2.6%5BEC/RN%20Number%5D%20AND%20%28cephalosporinase%5BAll%20Fields%5D%20OR%20%22class%20c%20beta%20lactamase%22%5BAll%20Fields%5D%29&cmd=DetailsSearch proteins] | ||
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