Sandbox Reserved 1066: Difference between revisions
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= Introduction = | = Introduction = | ||
''Mycobacterium tuberculosis'' very-long-chain fatty acyl-CoA synthetase, also known as FadD13, is unique within its class in regards to its ability to house lipid substrates longer than itself. Most FadD class proteins exist as integral membrane proteins involved in lipid transport into the cell. FadD13 is unique structurally in that it exists as a peripheral protein on the inside of the cell membrane. This feature is key in the mechanistic basis for FadD13's transport of fatty acids of length C24-C26.<ref name="Our Paper">PMID: 22560731</ref> | ''Mycobacterium tuberculosis'' very-long-chain fatty acyl-CoA synthetase, also known as FadD13, is unique within its class in regards to its ability to house lipid substrates longer than itself. Most FadD class proteins exist as integral membrane proteins involved in lipid transport into the cell. FadD13 is unique structurally in that it exists as a peripheral protein on the inside of the cell membrane. This feature is key in the mechanistic basis for FadD13's activation and transport of fatty acids of length C24-C26 through the two step addition of [https://en.wikipedia.org/wiki/Acyl-CoA Acyl-CoA](Figure 1).<ref name="Our Paper">PMID: 22560731</ref> | ||
FadD13 may be important in the virulence of [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis''], the etiological agent of [https://en.wikipedia.org/wiki/Tuberculosis tuberculosis], and has emerged as possible target for novel therapeutic agents.<ref name="JT">PMID: 20454815</ref> | FadD13 may be important in the virulence of [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis ''Mycobacterium tuberculosis''], the etiological agent of [https://en.wikipedia.org/wiki/Tuberculosis tuberculosis], and has emerged as possible target for novel therapeutic agents.<ref name="JT">PMID: 20454815</ref> | ||
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== General mechanism for the activation of fatty acids == | == General mechanism for the activation of fatty acids == | ||
[[Image:acyl coa synthetase.jpg|400 px|left|thumb|Figure | [[Image:acyl coa synthetase.jpg|400 px|left|thumb|Figure 1: Representation of the two-step reaction catalyzed by FadD13]] | ||
== Structural basis for housing lipid substrates longer than the enzyme == | == Structural basis for housing lipid substrates longer than the enzyme == | ||
