Sandbox Reserved 431: Difference between revisions
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==Quiz Question 2== | ==Quiz Question 2== | ||
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The above two green scenes highlight the chiral center of the MTH1 inhibitor called crizotinib. Research has shown that the | The above two green scenes highlight the chiral center of the MTH1 inhibitor called crizotinib. Research has shown that the (S)-enantiomer binds with more affinity to it's MTH1 substrate but that it is not due to interaction with the protein itself at the binding site. | ||
<Structure load='4c9x' size='300' frame='true' align='left' caption='S-Enantiomer of Inhibitor at Binding Site' scene='48/483888/S-enantiomer_zoom_in/4'/> | <Structure load='4c9x' size='300' frame='true' align='left' caption='(S)-Enantiomer of Inhibitor at Binding Site' scene='48/483888/S-enantiomer_zoom_in/4'/> | ||
<Structure load='4c9x' size='300' frame='true' align='center' caption='R-Enantiomer of Inhibitor at Binding Site' scene='48/483888/R-enantiomer_zoomed_in/1'/> | <Structure load='4c9x' size='300' frame='true' align='center' caption='(R)-Enantiomer of Inhibitor at Binding Site' scene='48/483888/R-enantiomer_zoomed_in/1'/> | ||
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[[Image:S-crizo.gif|300px|left|thumb| Crizotinib Structure Modified from adooq.com]] | [[Image:S-crizo.gif|300px|left|thumb| Crizotinib Structure Modified from adooq.com]] | ||
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Using the green scenes and the structure image can you see an unfavorable interaction near the chiral center in the | Using the green scenes and the structure image can you see an unfavorable interaction near the chiral center in the (R)-enantiomer that does not exist in the (S)-enantiomer? Explain. | ||
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The conformation of the enantiomer is ___________ unfavored. | The conformation of the enantiomer is ___________ unfavored. | ||
