Sandbox Reserved 433: Difference between revisions
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GSK-3 beta has various inhibiters; one example is AMP-PMP. These inhibitors bind to the N-terminus of the ligand on the GSK-3 beta complex, a result of the classical binding mechanism for a protein kinase. However, in the case of staurosporine (another inhibitor), it is unable to classically bind to the N-terminus of the ligand on the GSK-3 beta complex. This is because, in a GSK-3 beta complex with staurosporine, the ligand in question has an incompatible angle at the N-terminus, thus failing to undergo classical binding<ref name="paper" />. | GSK-3 beta has various inhibiters; one example is AMP-PMP. These inhibitors bind to the N-terminus of the ligand on the GSK-3 beta complex, a result of the classical binding mechanism for a protein kinase. However, in the case of staurosporine (another inhibitor), it is unable to classically bind to the N-terminus of the ligand on the GSK-3 beta complex. This is because, in a GSK-3 beta complex with staurosporine, the ligand in question has an incompatible angle at the N-terminus, thus failing to undergo classical binding<ref name="paper" />. | ||
What type of bonding does GSK-3 beta exhibit with staurosporine, and which of its residues form this type of bond? | What type of bonding does GSK-3 beta exhibit with staurosporine, and which of its residues form this type of bond? If needed, a green screen of the complex can be found below. | ||
<scene name='48/483890/Ligand_bonding_type/1'>View Complex</scene> | <scene name='48/483890/Ligand_bonding_type/1'>View Complex</scene> | ||
