Sandbox Reserved 433: Difference between revisions

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=='''Glycogen Synthase Kinase 3 Beta'''==

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==Quiz Question 1==

GSK-~~3 beta~~ has various inhibiters; one example is AMP-PMP. These inhibitors bind to the N-terminus of the ligand on the GSK-~~3 beta~~ complex, a result of the classical binding mechanism for a protein kinase. However, in the case of staurosporine (another inhibitor), it is unable to classically bind to the N-terminus of the ligand on the GSK-~~3 beta~~ complex. This is because, in a GSK-~~3 beta~~ complex with staurosporine, the ligand in question has an incompatible angle at the N-terminus, thus failing to undergo classical binding<ref name="paper" />.

GSK-3β has various inhibiters; one example is AMP-PMP. These inhibitors bind to the N-terminus of the ligand on the GSK-3β complex, a result of the classical binding mechanism for a protein kinase. However, in the case of staurosporine (another inhibitor), it is unable to classically bind to the N-terminus of the ligand on the GSK-3β complex. This is because, in a GSK-3β complex with staurosporine, the ligand in question has an incompatible angle at the N-terminus, thus failing to undergo classical binding<ref name="paper" />.

What type of bonding does GSK-~~3 beta~~ exhibit with staurosporine, and which of its residues form this type of bond? If needed, a green screen of the complex can be found below.

What type of bonding does GSK-3β exhibit with staurosporine, and which of its residues form this type of bond? If needed, a green screen of the complex can be found below.

<scene name='48/483890/Ligand_bonding_type/1'>View Complex</scene>

Sandbox Reserved 433: Difference between revisions

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 =='''Glycogen Synthase Kinase 3 Beta'''==
-<StructureSection load='1q3d' size='350' side='right' caption='A look at GSK-3 beta. pdbcode: 1q3d.' scene='Insert optional scene name here'>
+<StructureSection load='1q3d' size='350' side='right' caption='A look at GSK-3β. pdbcode: 1q3d.' scene='Insert optional scene name here'>
@@ Line 44: / Line 44: @@
 ==Quiz Question 1==
-GSK-3 beta has various inhibiters; one example is AMP-PMP. These inhibitors bind to the N-terminus of the ligand on the GSK-3 beta complex, a result of the classical binding mechanism for a protein kinase. However, in the case of staurosporine (another inhibitor), it is unable to classically bind to the N-terminus of the ligand on the GSK-3 beta complex. This is because, in a GSK-3 beta complex with staurosporine, the ligand in question has an incompatible angle at the N-terminus, thus failing to undergo classical binding<ref name="paper" />.
+GSK-3β has various inhibiters; one example is AMP-PMP. These inhibitors bind to the N-terminus of the ligand on the GSK-3β complex, a result of the classical binding mechanism for a protein kinase. However, in the case of staurosporine (another inhibitor), it is unable to classically bind to the N-terminus of the ligand on the GSK-3β complex. This is because, in a GSK-3β complex with staurosporine, the ligand in question has an incompatible angle at the N-terminus, thus failing to undergo classical binding<ref name="paper" />.
-What type of bonding does GSK-3 beta exhibit with staurosporine, and which of its residues form this type of bond? If needed, a green screen of the complex can be found below.
+What type of bonding does GSK-3β exhibit with staurosporine, and which of its residues form this type of bond? If needed, a green screen of the complex can be found below.
 <scene name='48/483890/Ligand_bonding_type/1'>View Complex</scene>